HOUSE STAFF RESEARCH 2008-2009
Published and Submitted Manuscripts
Weiner DE, Bartolomei KR, Scott T, Price LL, Griffith JL, Rosenberg I, Levey AS, Folstein MF, Sarnak MJ. Albuminuria, Cognitive Functioning and White Matter Hyperintensities in Homebound Elders.. American Journal of Kidney Diseases. 2009 Mar; 53(3): 438-447.
Kate Berg -Two chapters in the new 2008 edition of 5-Minute Clinical Consult, edited by Frank Domino. My chapters are "Tuberculosis" and "Miliary Tuberculosis."
Falcone EL, Alam A, Tangri N. “Mycobacterium avium complex peritonitis in a patient on continuous ambulatory peritoneal dialysis”. Clin Nephro
Falcone, EL, Mangili, A, Polak, JF, Skinner, SC, Wanke, CA. “Framingham Risk Score and Markers of Early Atherosclerosis in a Cohort of Subjects Infected with HIV”.
Original research: Submitted to HIV Medicine
Falcone EL, Mangili A, Polak JF, Tang AM, Woods MN, Jones C, Wanke CA. “Serum Micronutrient Levels and Markers of Subclinical Atherosclerosis in HIV-Infected Adults”.Submitted to The American Journal of Clinical Nutrition
Maron MS, Finley JJ et al. "Prevalence, Clinical Significance, and Natural History of Left Ventricular Apical Aneurysms in Hypertropic Cardiomyopathy." Circulation. 2008;118: 1541-1549.
John J. Finley IV, MD; Marvin A. Konstam, MD; James E. Udelson, MD. Arginine Vasopressin Antagonists for the Treatment of Heart Failure and Hyponatremia.
Circulation 2008;118;410-421
Haseeb Jafri, Alawi A. Alsheikh-Ali, Paula Mooney, Carey D. Kimmelstiel, Richard H. Karas, Jeffery T. Kuvin. Extended-release niacin reduces LDL particle number without changing total LDL cholesterol in patients with stable CAD. J Clin Lipidol. 2009; 3: 45-50.
Haseeb Jafri, Richard H. Karas, Jeffrey T. Kuvin. Effects of Niacin on LDL Particle Number. Clinical Lipidol. 2009; 4: 565-571.
Kevin Heffernan, Richard H. Karas, Eshan A. Patvardhan, Haseeb Jafri, Jeffrey T. Kuvin. Peripheral arterial tonometry for risk stratification in men with coronary artery disease. Clin Cardiol. [In Press]
Haseeb Jafri, Alawi A Alsheikh-Ali, Richard H. Karas. Low Levels of High-Density Lipoprotein Cholesterol are Associated With Increased Cardiovascular Risk in Statin-Treated Patients: Evidence from Randomized Controlled Trials. [Submitted].
Haseeb Jafri, Alawi A Alsheikh-Ali, Richard H. Karas. HDL-Cholesterol and the Risk of Incident Cancer in Randomized Controlled Trials of Lipid Altering Therapy. [Submitted].
Haseeb Jafri, Alawi A Alsheikh-Ali, Richard H. Karas. Statin-Mediated Reduction in Risk of Stroke Is Independent of the Extent of Low-Density Lipoprotein Cholesterol Lowering. [Submitted].
Jafri H, Alsheikh-Ali A, Karas RH. Higher HDL-C Levels are Associated with a Lower Risk of Cancer. Submitted
Dale Okorodudu, Marwan Jumean, Abel Romero-Corral, Virend Somers, Francisco Lopez-Jimenez. Diagnostic Performance of Body Mass Index to Diagnose Body Adiposity: A Systematic Review and Meta-Analysis. “Submitted to International Journal of Obesity”
Randal J Thomas, Kashish Goel, Marwan Jumean, Charles Mullany, Brian Lahr, Ray Gibbons. Short- and Long-term Impact of an In-patient Quality Improvement Initiative: Results of the CABG-GAP Practice Improvement Project. “Submitted to American Heart Journal”
Jumean MF, Vickers-Douglas KS, Kopecky SL, Dierkhising R, Squires RW, Lopez-Jimenez F, Thomas RJ. Effect of a Physical Activity DVD on Attitudes toward Exercise and Weekly Exercise Time in Patients at Risk of Coronary Artery Disease: A Randomized Trial “In preparation”
Alsheikh-Ali AA, Homer M, Maddukuri PV, Kalsmith B, Estes III NAM, Link MS. Time-Dependence of Appropriate Implantable Defibrillator Therapy in Patients with Ischemic Cardiomyopathy - J Cardiovasc Electrophysiol. Feb 12, 2008
Kalsmith B, Mehta S, Lee H. Current Management of Portal Hypertension Submitted to the Journal of Hepatology
Kramer DG, Trikalinos TA, Kent DM, Antonopoulos GV, Konstam MA, Udelson JE. Quantitative Evaluation of Drug/Device on Ventricular Remodeling as Predictors of Therapeutic Effects on Mortality in Patients With Heart Failure and Reduced Ejection Fraction: A Meta-Analytic Approach. Abstract presented at American College of Cardiology 2008 annual conference. Publication in progress.
Goldberg RJ, Kramer DG, Yarzebski J, Lessard D, Gore JM. Prehospital transport of patients with acute myocardial infarction: a community-wide perspective. Heart & Lung: The Journal of Acute and Critical Care 2008;
Abstracts and Presentations
Keith Bartolomei, Mark J Sarnak, Marshal Folstein, Daniel E Weiner
"Orthostatic Hypertension and Hypotension in the Elderly" Accepted for presentation at the ASN's Renal Week 2008 in Philadelphia
Weiner, D., Bartolomei, K., Price, L., Scott, T., Griffithy, J., Levey, A., Rosenberg, I., Folsteine, M., Sarnak, M.. (2008, November). Albuminuria, Cognitive Function and White Matter Hyperintensities in Homebound Elders. Poster presented at: American Society of Nephrology; Philadelphia, PA, 2008
Bartolomei, K., Sarnak, M., Folstein, M., Weiner, D. (2009, October). Cystatin C, Albuminuria, Cognition and Cerebrovascular Disease in the Elderly. Poster to be presented at American Society of Nephrology, San Diego, CA.
Dad M, Jafri H, Alsheikh-Ali A, Abourjaily P, Link MS, Estes NAM III, Karas RH. Sub-optimal Lipid Levels are Highly Prevalent in Patients with Ischemic Cardiomyopathy and Implantable Defibrillators. Submitted to ACC
Lauren Dowling, John Leung, Kathleen Viveiros "Risk of Non-Melanoma Skin Cancer in Autoimmune Hepatitis" will be presented at the 2009 AASLD Annual Meeting.
Lauren Epstein; M.B. Laws; Y.S. Bradshaw; Y. Lee; A. Greenhill; T. Taubin; E. Howe; M. Nguyen; W. Rogers; I.B. Wilson . Shorter Office Visits tend to be less patient-centered. Presented at the Society of General Internal Medicine national meeting in Miami, 2009.
E. Falcone. A lung mass with “minimal” effects. Poster Presentation: March 2008
The Society of General Internal Medicine.
Emelia Falcone and C. Wanke. Serum Micronutrient Levels and Markers of Subclinical Atherosclerosis in HIV-Infected Adults Poster Presentation: October 2008
The Infectious Disease Society of America (IDSA)
Emelia Falcone and C. Wanke. Framingham Risk Score and Markers of Early Atherosclerosis in Cohort of HIV Infected Subjects. Abstract presented at Conference on Retroviruses and Opportunistic Infections, Montreal, CA, 2009.
Daria Homenko "Acute pancreatitis within hours of 6-mercaptopurine use" was accepted at the 2009 Advances in Inflammatory Bowel Diseases Crohn's & Colitis Foundation's Research & Clinical Conference in December.
Daria Philip F Binkley, Haseeb Jafri. Abstract 1009-23: Patients With Dilated Cardiomyopathy Who Have Recovered Normal Ventricular Function Remain at Increased Risk for Sudden Death. JACC 51: S_A49. Presented at the 2008 American Cardiology of Cardiology Scientific Sessions, Chicago, Illinois 2008.
Haseeb Jafri, Jeffrey T Kuvin, Alawi A Alsheikh-Ali, Paula Mooney, Carey D Kimmelstiel, and Richard H Karas. Abstract 5144: Extended-Release Niacin Reduces LDL-C Particle Number Even In The Absence Of Changes In Total LDL-C Levels. Circulation 118: S_1150-c. Presented at the 2008 American Heart Association Scientific Sessions, New Orleans, Louisiana. 2008.
Haseeb Jafri, Alawi A Alsheikh-Ali, Richard H Karas. Abstract 1012-79: Absolute LDL-C Lowering Is a Better Predictor of Risk Reduction Than Percent LDL-C Lowering in Lipid Intervention Trials. JACC 53: S_A200. Presented at the 2009 American Cardiology of Cardiology Scientific Sessions, Orlando, Florida, 2009.
Alawi A Alsheikh-Ali, Haseeb Jafri, Richard H. Karas. Abstract 1012-84: Magnitude of Benefit in Statin Trials is Directly Related to On-Treatment Differential in Low-Density Lipoprotein Cholesterol. JACC 53: S_A202. Presented at the 2009 American Cardiology of Cardiology Scientific Sessions, Orlando, Florida, 2009.
Alawi A Alsheikh-Ali, Haseeb Jafri, Carey Kimmelstiel, Richard H Karas. Abstract 1012-90: Statin-Mediated Reduction in Risk of Stroke Is Independent of the Extent of Low-Density Lipoprotein Cholesterol Lowering. JACC 53: S_A203. Presented at the 2009 American Cardiology of Cardiology Scientific Sessions, Orlando, Florida, 2009.
Haseeb Jafri, Alawi Alsheikh-Ali, Richard H Karas. Abstract 1048-70: High Density Lipoprotein Cholesterol Levels Contribute Significantly to Residual Coronary Heart Disease Risk in Statin-Treated Patients. JACC 53: S_A225. Presented at the 2009 American Cardiology of Cardiology Scientific Sessions, Orlando, Florida, 2009.
Leon Shao, Haseeb Jafri, Alawi Alsheikh-Ali, Richard Karas. Abstract 1013-95: Intensive LDL-C Reduction Can Induce Cholesterol Plaque Regression: Data From Coronary Intravascular Ultrasound and Coronary Angiography Studies. JACC 53: S_A419. Presented at the 2009 American Cardiology of Cardiology Scientific Sessions, Orlando, Florida, 2009.
Haseeb Jafri, Alawi A Alsheikh-Ali, Richard H Karas. High-Density Lipoprotein Cholesterol Levels are Inversely Associated With Cancer Risk. To be presented at the 2009 American Heart Association Scientific Sessions, Orlando, Florida, 2009.
Haseeb Jafri, Alawi A Alsheikh-Ali, Richard H Karas. Statin Therapy Does Not Reduce the Increased Cardiovascular Risk Associated with Low Levels of High-Density Lipoprotein Cholesterol: Evidence from Randomized Controlled Trials. To be presented at the 2009 American Heart Association Scientific Sessions, Orlando, Florida 2009.
Jafri H, Alsheikh-Ali A, Mooney P, Kimmelstiel CD, Karas RH, Kuvin JT. Extended-Release Niacin reduces LDL-C particle number even in the absence in total LDL-C Levels. Will be presented at AHA 2008 – published in Circulation
Dena E. Rifkin MD, MS; Alin John, MD; Jill Melendez Young, MD, MS; Lisa McDevitt, Pharm. D; Richard Freeman, MD; Ronald D. Perrone, MD Thymoglobulin use, leukopenia, and adverse events in the first post-transplant year: Retrospective analysis of 85 consecutive patients. Presented at the American Society of Nephrology meeting in San Diego in Oct, 2009.
Marwan Jumean Metabolic Syndrome: Impact of Receiving the Diagnosis and Education Intervention on Cardiovascular Risk Factor Modification and Willingness to Change. Presented at European Society of Cardiology Congress, September 2008,
Marwan Jumean. The Diagnostic Performance of Body Mass Index to Diagnose Body Fatness: A Meta-analysis. Poster presentation at The Scientific Meeting of the National Obesity Society, October 2008
Jumean Marwan, Kashish Goel, Mullany Charles, Gibbons Raymond, Thomas Randal. In-Patient Quality Improvement Initiative and Long-term Mortality after Coronary Artery Bypass Graft Surgery. Poster Presentation at the AHA Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke Conference, Washington D.C., April 2009. Circ Cardiovasc Qual Outcomes 2009;2e8
Goel K, Jumean MF, Lahr BD, Thomas RJ. Use of preventive medications and impact on long-term mortality after Coronary Artery Bypass Graft surgery. Poster presentation. American Association of Cardiovascular and Pulmonary Rehabilitation annual meeting, October 1-3, 2009, Pittsburgh. J Cardiopulm Rehabil Prev. 2009 Jul-Aug;29(4):262-74. PMID: 19628990
Jumean Marwan, Okorodudu Dale, Romero-Corral Abel, Lopez-Jimenez F, Somers V: The Diagnostic Performance of Body Mass Index to Diagnose Body Fatness: A Meta-analysis. Poster presentation at The Scientific Meeting of the National Obesity Society, October 2008.
Jumean Marwan, Yoel Korenfeld, Vickers-Douglas K, Lopez-Jimenez F. Metabolic Syndrome: Impact of Receiving the Diagnosis and Education Intervention on Cardiovascular Risk Factor Modification and Willingness to Change. European Society of Cardiology Congress, September 2008, “Accepted for a poster presentation”
Vickers-Douglas KS, Kopecky SL, Jumean MF: Effect of a Physical Activity DVD on Attitudes toward Exercise and Weekly Exercise Time in Patients at Risk of Coronary Artery Disease: A Randomized Trial. Oral presentation at the Mayo Clinic Preventive Cardiology Conference, April 2008
Alsheikh-Ali AA, Kalsmith B, Estes III NAM, Link MS Limited Relevance of Invasive Electrophysiologic Testing in Patients Meeting Current Primary Prevention Indications for an Implantable Cardioverter-Defibrillator. Abstracts- Accepted to ACC.
Makati K, Kalsmith B, Baig S, Mackey E, Kalin J, Homoud M, Weinstock J, Estes III NAM, Link MS, Cardiac Arrest Survivors with Concomitant Myocardial Infarction Continue to Have a High Recurrence of Ventricular Arrhythmia- Accepted to ACC.
Alsheikh-Ali AA, Makati KJ, Kalsmith B, Estes III NAM, III, Link MS, No Difference in ICD Treated Ventricular Arrhythmias in Patients with Left Ventricular Ejection Fraction 31-35 % Compared to ≤ 30 %. Abstracts- Accepted to the ACC.
Christopher Madias, Benjamin Kalsmith, Alawi A. Alsheikh-Ali, N. A. Mark Estes III, Mark S. Link, Natesa G. Pandian, Martin S. Maron Hypokalemia is associated with adverse hospital course in patients with stress cardiomyopathy Abstract- Accepted to HRS 2008:
Kramer DG, Trikalinos TA, Kent DM, Antonopoulos GV, Konstam MA, Udelson JE. Quantitative Analysis of Ventricular Remodeling as a Surrogate for Drug/Device Effects on Mortality in Patients with Heart Failure and Reduced Ejection Fraction: an Updated Analysis. Abstract submitted to American College of Cardiology 2008
Tim Kyin. 'Role of Caspase-3 in Liver Transplant Complications' Accepted for presentation at the 22nd International Congress of The Transplantation Society in Australia.
Evelyn Leechawengwongs. Sclerosing Cholangitis Associated with Thymoma and Immunodeficiency (Good Syndrome). Accepted for the ACAAI Annual Meeting in Seattle, November 8, 2008.
Kapur NK, Nguyen TA, Yunis AA, Newfell BG, Trivedi A, Parpos P, Sahasrabudhe NA, Cross BJ, Weintraub A, Kimmelstiel C, Jaffe IZ, Mendelsohn ME Soluble Endoglin and FLT-1 Expression in ST-elevation Myocardial Infarction (STEMI): Markers of Angiogenic Imbalance. Accepted for presentation at SCAI meeting.
Kapur NK, Nguyen TA, Yunis AA, Newfell BG, Trivedi A, Parpos P, Sahasrabudhe NA, Cross BJ, Weintraub A, Kimmelstiel C, Jaffe IZ, Mendelsohn M. Soluble Endoglin and FLT-1 Expression in ST-elevation Myocardial Infarction (STEMI): Markers of Angiogenic Imbalance. Presented at Society for Cardiovascular Angiography and Interventions in May, 2009.
Kapur NK, Nguyen TA, Yunis AA, Cross BJ, Jaffe IZ, Mendelsohn ME. Soluble fms-like Tyrosine Kinase (sFLTI): A Biomarker of Endothelial Origin in Acute ST-segment Elevation Myocardial Infarction (STEMI). To be presented at American Health Association in Fall, 2009.
Ethan J. Rowin, MD, Evan Appelbaum, MD, Caitlin Harrigan, BA, Jacki Buros, BA Leah Biller, BA, C. Michael Gibson, MD, MS, John R. Lesser, MD, Tammy S. Haas, RN, James E. Udelson, MD, Warren J. Manning, MD, Barry J. Maron, MD, Martin S. Maron, MD. Is the 12-lead Electrocardiogram of Value in the Prognostic Assessment of Patients with Hypertrophic Cardiomyopathy? To be presented at Society of Cardiac MRI in Arizona.
Kim Schelling. Curriculum for novice providers and trainees working in homeless shelters for women" For Poster presentation during the 136th APHA Annual Meeting & Exposition in San Diego, CA.
Shao L, Jafri H, Alsheikh-Ali A, Karas RH. Intensive LDL-C Lowering can Induce Cholesterol Plaque Regression: Data from Coronary Intravascular Ultrasound and Angiography Studies. Submitted to ACC
Venugopal, Radhika; Lee, Hannah; Salomon, Robert; Kaplan, Marshall M .Treatment of Recurrent Primary Biliary Cirrhosis (PBC) after Orthotopic Liver Transplantation (OLT). Submitted to AASLD.
BenWessler , J. Udelson, M. Konstan, D. Kent , T. Trikalinos, D. Kramer. Drug and Device Effects on Peak Oxygen Consumption as a Predictor of Therapeutic Effects on Mortality in Heart Failure Randomized Trials Presented at the American Heart Association Conference 2009.
Cynthia Yan, Nick Hill, Francisco Soto, Ioana Preston, Jean-Luc Vachiery, Robyn Barst. Long-term Outcomes in Patients Transitioned From Intravenous Prostacyclin to Subcutaneous Prostacyclin Therapy. Accepted for presentation at the Chest Conference in Philadelphia 10/08.
Ongoing Projects
Monica Campo , Matt Cohn, Delvina Hasimja , Evelyn Kao, Sienna Moran and Hala Moukhachen. (with P. Castaldi) Meta-analysis of the genetics of COPD.
Mike Chaknos (with Mark Sarnak) Looking at CV risk stratification and outcomes on stress tests in CKD patients.
Marcie Claybon (with L.Stevens) Studies of GFR estimation among different racial groups.
Misha Dad (with H. Jafri and A. Al-Sheikh) abstract about lipids in pt with ICD's
Jimmy Davis (with R. Karas) Study looking at the relationship of PCI patients on/off statins and its effect on post-cath bleeding events
Lauren Dowling (with I. Gan) Retrospective study looking at ischemic colitis in the young.
Dave Drew (with S. Rao and V. Balakrishnan) Genetic polymorphisms in type 1 diabetic nephropathy.
John Duell (with A. Garlitski). Gender Differences in Atrial Fibrillation.
Liana Falcone (with Christine Wanke and Alexandra Mangili) research project looking at ultra low viral loads and surrogate markers of atherosclerosis. In addition, we are currently working on the longitudinal data for the above mentioned cross-sectional studies.
Kristen Farwell Endoscopic Mucosal Resection to removal large sessile cecal polyps. (with R. Freeman) Reviewing the UNOS database for transplantation and HCC, looking at overall outcomes in HCC transplants.
Adi Ganz (with N. Pandian) 3D Speckle Tracking Echocardiography
Daria Homenko(with K. Viveiros) Looking at colitis in patients taking Cellcept after kidney & liver transplants.
(with J. Weinstock and J. Leung ) Recurrent oral aphthous ulcers and its association with subclinical inflammatory bowel disease
(with K. Viveiros) Is diverticulosis a risk factor for recurrent clostridium difficile infection.
(with K. Viveiros and H. Alilson) Elevated liver function tests and their association with obstructive sleep in young obese individuals.
Anand Kenia (with M. Link) meta-analysis looking at the use and safety of adenosine in wide complex tachycardias.
Maria Krassnilnikova (with D. Weiner and M. Sarnak) Looking at chronic kidney disease,, risk factors (traditional as well as non-traditional) and outcomes (cardiovascular, stroke and mortality).
Maria Krassnilnikova – Working on a paper on Longitudinal estimates of GFR and Cardiac and Mortality Outcomes and another one on Lipids and Outcomes in patients with GFR below 60 as compared to those with GFR above 60.
Max Lee (with R. Karas). Project looking at adherence rates for patients taking niacin
Evelyn Leechawengwongs (with A. Simon) The role of STAT3 in asthma.
Samar Malaeb (with A. Pittas) The effect of dietary macronutrient composition on short term energy-regulating gastrointestinal hormones. A systematic review
Sema Mehta (with L. Davidson, D, Poutsiaka and H. Boucher) Looking at posaconazole and break through fungal infections.
Tuan Nguyen (with M. Link and A. Alshiekh-Ali) Risk and Predictors of One Year Mortality after ICD implantation
Ross Okimoto (with K. Miller) case report on Paraneoplastic Hypercalcemia in Chronic Myelomonocytic Leukemia.
Rusty Phillips (with K. Miller) case report about a patient with genetically identical relapse of CLL 10 years post-transplant.
Rob Piotrowski (with A. Garlitski) Systematic review of VT ablations in the setting of scarred myocardium secondary to MI.
Andrew Root (with D.Poutsiaka) Working on a retrospective case review of the impact of Cytomegalovirus reactivation on patient outcomes after hematopoietic stem cell transplantation.
Rebecca Sessashai (with M. Sarnak) Relationship between Apolipoprotein E and the incidence and progression of chronic kidney disease.
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Leon Shao (with R. Karas and A. Al-Shiekh-Ali) Metaanalysis looking at the magnitude of LDL reduction and it's correlation with atherosclerotic plaque regression. I submitted the abstract for this year's ACC conference. (with J. Kuvin) working on the TRIUMPH study, a multicenter study looking at discrepancies in MI care between different socioeconomic backgrounds
Evangeline Thibodeau (with Dr Hibberd and Dr. Chomat) Study investigating the impact of non-traditional medicines on use of anti-retroviral therapy among HIV-infected individuals in India. The study involves on-site patient interviews as well as blood samples and testing of non-traditional products.
(with Dr Davidson and Dr. Hibberd) Flu Vaccine study, looking at Probiotics as immune adjuvants to the mucosal fu vaccine.
(with H. Boucher) Designing a web-based program primarily for residents that are on the ID consults elective (also to be used by medical students).
Ben Wessler (with M. Link) Looking at ambient air pollution and its relationship to supraventricular and ventricular arrhythmias.
Drug and Device Effects on BNP as a Predictor of Therapeutic Effects on Mortality in Heart Failure Randomized Trials with Dr. Udelson, Dr. Konstam, Dr. Kent, Dr. Trikalinos, Dr. Kramer.
Rhadikha Venugopal (with M. Link and A. Al Sheikh Ali ) Retrospective study assessing the risk of mortality (sudden cardiac death and all cause mortality) in ICD recipients with Chronic Kidney Disease.
Roxanne Wadia (with G. Strauss) Looking at the "healthy volunteer effect" in random population based trials.
Diana Winston (with C. Wanke) Studying the association between HIV and Hepatitis C infections and lipid levels among a cohort of Argentinean drug users.
Carrie Wong (with J. Wong) working on a meta-analysis on nucleoside and nucleotide treatments and their effects on E antigen, viral load and liver function tests in patients with chronic hepatitis B.