John E. Mignano, MD
Clinic Director, Radiation Oncology
Publications
Jamall, I.S., J.E. Mignano, V.D. Lynch, J.M. Bidanset, C. Lau-Cam, and
Greening. Protective effects of zinc sulfate and l-lysine on acute
ethanol toxicity in mice. Environ. Res. 19: 112-120, 1979.
Segal, A., J.J. Solomon, J. Mignano, and J. Dino. The isolation
and characterization of 3-(2-carboxyethyl)cytosine following in vitro
reaction of the direct-acting carcinogen beta-propriolactone with
calf thymus DNA. Chem. -Biol. Interactions 35: 349-361, 1981.
Pietronigro, D.D., J.E. Mignano, and H.B. Demopoulos. Direct
quenching of adriamycin radicals by coenzyme Q10 and tetrazolium
salts. Biochem. Pharmacol. 32: 1441-1444, 1983.
Zurlo, J., P.C, Eustice, J.E. Mignano, M.C. Poier, and J.D. Yager.
Effects of carcinogen treatment on rat liver DNA synthesis in vivo
and on nascent DNA synthesis and elongation in cultured
hepatocytes. Mutation Res. 161: 143-154, 1986.
Sebti, S.M., J.E. Mignano, S. Srimatkandanda, and J.S. Lazo.
Bleomycin hydrolase: molecular cloning and sequencing reveals
membership in the thiol esterase family. Biochem. 28: 6544-6548,
1988.
Morris, G., J.S. Mistry, J.P. Jani, J.E. Mignano, S.M. Sebti, and J.S.
Lazo. Neutralization of bleomycin hydrolase by an epitope-specific
antibody. Molec. Pharm. 42: 57-62, 1992.
Mignano, J.E., M.L. Zahurak, A. Chakravarthy, S. Piantadosi,
W.C. Dooley, and Gage. Significance of axillary lymph node
extranodal soft tissue extension and indications for post-mastectomy irradiation. Cancer 86: 1258-62, 1999.
Mignano, J.E., M. Engler, J.-S. Tsai, and D. Wazer. Comparison of
radiobiological modeling for one- and two-isocenter dose distributions
applied to ellipsoidal radiosurgery targets. Internat’l. J. Radiat.
Oncol., Biol. & Physics 49: 833-7, 2001.
Tsai, J.-S., M.J. Rivard, M. J. Engler, J.E. Mignano, D.E. Wazer, and
W.A. Shucart. Determination of the 4 mm Gamma Knife helmet
relative output factor using a variety of detectors. Medical Physics
30:986-92, 2003.
Rivard, M.J., Zinkin, H.D.,Mignano, J.E., and Kimmelstiel, C.D.
Treatment of in-stent restenosis for saphenous vein grafts using
intravascular brachytherapy: regulatory chllenges and clinical
application. J. Invasive Cardiol.16:96-99, 2004.
Zinkin, H.D., Rivard, M.J., Mignano, J.E., and Wazer, D.E. Analysis of
dose conformity and normal-tissue sparing using two different IMRT
prescription methodologies for irregularly shaped CNS lesions. Int. J.
Radiat. Oncol. Biol. Phys. 59:285-92, 2004.
Mignano, J.E.and Rivard, M.J. Intravascular brachytherapy using 90Sr
for saphenous vein grafts having diameters ranging from 2.0 to 5.0
mm. Brachytherapy 3:173-178, 2004.
Gage, , Mignano, J.E., Piantadosi, S., Henderson, G, Chakravathy, A.,
and Dooley, W.C. Local recurrence after mastectomy in patients
with T3pN0 breast carcinoma treated without postoperative radiation
therapy. J. Clin. Oncol. (in press, 2006).
Reviews and Book Chapters
Lazo, J.S., J.E. Mignano, and S.M. Sebti. Pulmonary metabolic inactivation of bleomycin and protection from drug-induced lung injury. In: Organ Directed Toxicities of Anticancer Drugs (M. Hacker, T. Tritton, and J.S. Lazo, eds.) Martinus Nijhoff: , pp. 128-139, 1987.
Lazo, J.S., S.L. Kelley, and J.E. Mignano. Manipulation of antineoplastic drug sensitivity and resistance by DNA transfection. In: Mechanisms of Drug Resistance in Neoplastic Cells, the Ninth Annual Bristol-Myers Symposium on Cancer Research. Academic Press: NY, pp. 349-370, 1988.
Mignano, J.E. Review for National Boards Comprehensive Examination. First edition. (J.S. Lazo, B.R. Pitt, and J.C. Glorioso, III, eds.), Harwal Publishing Co., 1991.
Abstracts
Mignano, J.E.and J.D. Yager. Detection of transforming activity in human hepatoma cell line DNA following transfection into NIH 3T3 cells. 69th FASEB, 4672, 1985.
Lazo, J.S., A.E. Filderman, and J.E. Mignano. Pulmonary pharmacokinetic aspects of intratracheally instilled plasmid DNA. Amer. Rev. Resp. Dis. 135: A502, 1987.
Mignano, J.E., S.M. Sebti, and J.S. Lazo. Isolation and characterization of a partial-length cDNA clone for rabbit lung bleomycin hydrolase. 72nd FASEB, 6157, 1988.
Mignano, J.E.,S.M. Sebti, and J.S. Lazo. Characterization of a partial-length cDNA clone for bleomycin hydrolase reveals homology with the active site of thiolproteases. 73rd FASEB, 5345, 1989.
Mignano, J.E., Gage, S. Piantadosi, A. Chakravarthy, and W. Dooley. Local recurrence after mastectomy in patients with T3N0 breast carcinoma treated without postoperative irradiation. 19th Annual San Antonio Breast Cancer Symposium, 230, 1996.
Mignano, J.E.,Gage, G. Henderson, S. Piantadosi, A. Chakravarthy, and W. Dooley. Recurrence patterns in patients with node-positive breast carcinoma (T1-T3) and axillary extracapsular extension (ECE), treated without postoperative irradiation. 20th Annual San Antonio Breast Cancer Symposium, 129, 1997.
Mignano, J. E., Kramer, J.-S. Tsai, M. Engler, and D. Wazer. Radiosurgery for ellipsoidal targets: Are single or multiple isocenter plans superior? 40th Annual American Society for Therapeutic Radiology and Oncology Meeting, 226, 1998.
Mignano, J.E.and Rivard, M.J. Intravascular brachytherapy using 90Sr for saphenous vein grafts having diameters ranging from 2.0 -5.0mm. Brachytherapy 2:44-5, 2003.
Rivard, M.J. and Mignano, J.E. Intravascular brachytherapy of saphenous vein grafts using 90Sr for extended radial ranges. Med. Phys. 30:1465-6, 2003.
Mignano, J.E.and Rivard, M.J. A review of clinical application of californium-252, Radiother. Oncol. 71:S136, 2004.
Rivard, M.J., Zinkin, H.D., Stapleford, L.J., Evans, K.E., Mignano, J.E. and Wazer, D.E., A radiobiological model for the relative biological effectiveness of high dose rate 252Cf brachytherapy, Radiother. Oncol. 71:S137, 2004.
Riesenburger, R.I., Zerris, V., Rivard, M.J., Mignano, J.E., Mahn, K., Shucart, W.A., Pain outcomes after Gamma Knife® treatment for trigeminal neuralgia patients previously treated with rhizotomy versus patients without previous surgical treatment, Proceedings of the 12th International Meeting of the Leksell Gamma Knife® Society, Vienna, Austria, 247, 2004.