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Contact Information
Telephone: 617-636-0563
Fax: 617-636-8329
Email: rperrone@tuftsmedicalcenter.org
For information on the HALT-PKD clinical trial call 617-636-8783 and ask for Peachy or Veronika.
For information on the TEMPO, BOSUTINIB, or OVERTURE studies please contact Yaicha Bryan at 617-636-7914 or ybryan@tuftsmedicalcenter.org.
Titles
Tufts Medical Center
Associate Chief, William B. Schwartz Division of Nephrology
Medical Director, Kidney Transplantation
Tufts University School of Medicine
Professor of Medicine
Polycystic Kidney Disease Foundation
Member, Scientific Advisory Committee (former Chairperson)
Member, Board of Trustees
Education
Undergraduate
B.S. with High Honors, Zoology 1971
Pennsylvania State University
University Park, PA
Medical School
Doctorate of Medicine 1975
Hahnemann Medical College (now Drexel University School of Medicine)
Philadelphia, PA
Training
Grady Memorial Hospital, Emory University, Atlanta GA
Medical Internship 1976
Medical Residency 1978
Boston University Medical Center, Boston, MA
Clinical Fellow in Nephrology 1980
Boston City Hospital, Boston University Medical Center, Boston, MA
Research Fellow in Nephrology 1982
Board Certification
ABIM, Board Certified in Nephrology 1982
Interests
Clinical
Dr. Perrone’s patient care interests are in polycystic kidney disease, general nephrology, acid-base disorders, hypertension, and kidney transplantation medicine. He is the Director of the Polycystic Kidney Disease Center.
Research
Dr. Perrone’s research interests are largely focused in the area of polycystic kidney disease, including slowing progression and determining the natural history of the extrarenal complications. In prior studies, he addressed the mortality of extrarenal complications of polycystic kidney disease after kidney failure treated by dialysis. He will continue this work in collaboration with Drs. Alan Collins and Blanche Chavers of the United States Renal Data System. Dr. Perrone also is the Principal Investigator of the Boston Patient Care Center of an NIH-funded multi-center clinical trial (HALT Progression in PKD, part of the Polycystic Kidney Disease Clinical Trials Network). This study uses angiotensin converting enzyme inhibitors in combination with angiotensin receptor blockers to slow the progression of polycystic kidney disease and utilizes the unique endpoint of kidney volume growth as assessed using magnetic resonance imaging. Tufts Medical Center is one of the four national HALT-PKD Study centers that will conduct this 6-year, $25 million study sponsored by the NIH. Drs. Perrone (the PI) and Miskulin direct the study that started in the winter of 2006.
Dr. Perrone is the Tufts Medical Center Principal Investigator of the TEMPO 3/4 study. TEMPO 3/4 is a global trial that is addressing the efficacy of the vasopressin-receptor antagonist tolvaptan to slow progression of polycystic kidney disease. The unique endpoint of kidney volume growth will be assessed using magnetic resonance imaging. Tufts Medical Center is one of 100 international TEMPO 3/4 Study centers.
Other Professional Activities
Professional Organizations
Polycystic Kidney Disease Foundation
Member, Scientific Advisory Committee (former Chairperson)
Member, Board of Trustees
Organ Procurement and Transplantation Network/United Network for Organ Sharing (OPTN/UNOS)
Region 1 Representative - OPTN/UNOS Kidney Transplant Committee
Chair, UNOS Region 1 Renal Transplant Oversight Committee.
Editorial Appointments
Dr. Perrone serves on the Editorial Board of the Clinical Journal of the American Society of Nephrology and is cystic kidney disease editor for Up-to-Date.
Policy-related Activities
Dr. Perrone was the Chair of the Planning Committee for the NKF/FDA workshop on Patient-reported Outcomes in Clinical Trials of Chronic Kidney Disease-related Therapies. The workshop was held in September 2010.
Dr. Perrone was appointed as Chairman of the Steering Committee for the Clinical Trial Endpoints and Therapies in Polycystic Kidney Disease workshop. The FDA and the PKD Foundation jointly sponsored this workshop. Click here for more information.
Dr. Perrone is a member of the Polycystic Kidney Disease Database Consortium. The goal of the Consortium is to establish a polycystic kidney disease clinical database.
Selected publications
Perrone RD, Abebe KZ, Schrier RW, Chapman AB, Torres VE, Bost J, Kaya D, Miskulin DC, Steinman TI, Braun W, Winklhofer FT, Hogan MC, Tahbari-Oskoui F, Kelleher C, Masoumi A, Glockner J, Halin NJ, Martin D, Remer E, Patel N, Pedrosa I, Wetzel LH, Thompson PA, Miller JP, Bae KT; HALT PKD Study Group, Meyers CM. Cardiac magnetic resonance assessment of left ventricular mass in autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol 2011;6:2508-15. Epub 2011 Sept 8.
Grantham JJ, Bennett WM, mTOR inhibitors and autosomal dominant polycystic kidney disease. N Engl J Med 2011;364:286-7; author reply 287-9.
Vora, N, Perrone, R, Bianchi, DW. Reproductive issues for adults with Autosomal Dominant Polycystic Kidney Disease (ADPKD). Am J Kidney Dis 2008;51:307-18.
Alam A, Perrone, RD. Managing cyst infections in ADPKD: an old problem looking for answers. Clin J Am Soc Nephrol; 4:1154-1155, 2009.
Chapman, AB, Torres VE, Perrone RD, Steinman TI, Bae KT, Miller JP, Miskulin DC, Oskoui FR, Masoumi A, Hogan MC, Winklhofer FT, Braun W, Thompson PA, Meyers CM, Schrier RW. The Halt Polycystic Kidney Disease Trials: design and implementation. Clin J Am Soc Nephrol;5102-9,2010.
Alam A, Perrone RD. Management of the ESRD in patients with autosomal dominant polycystic kidney disease. Adv Chron Kid Dis;17:164-172,2010.
Grantham JJ, Bennett WM, Perrone RD. mTOR inhibitors and automal dominant polycystic kidney disease. N Engl J Med; 364:286-287; author reply 287-289,2011.
Heffernan KS, Kuvin JT, Sarnak MJ, Perrone RD, Miskulin DC, Rudym D, Chandra P, Karas RH, Menon V. Peripheral augmentation index and vascular inflammation in autosomal dominent polycystic kidney disease. Nephrol Dial Transpl; epublication February 3, 2011.
Recent Awards and Honors
2000-2001 Tufts University School of Medicine Excellence in Teaching Award from the Third Year Medical Students
Citation for Excellence in Teaching by the Class of 2002 Tufts University School of Medicine
2001-2002 Tufts University School of Medicine Excellence in Teaching Award from the Third Year Medical Students
2007 Gift of Life Award - Outstanding Physician in Nephrology, National Kidney Foundation of MA, RI, NH, and VT
2009 Distinguished Faculty Award from TUSM
2011 Recognized as a “Top Doctors” and ranked among the top 1% of nation’s nephrologists by U.S. News & World Report
2011 Recognized as one of Boston’s best nephrologists by Boston Magazine.
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