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Leadership
Principal Investigator – Harry P. Selker, MD, MSPH. Dr. Selker is Dean of Tufts Clinical and Translational Research Institute, Executive Director for the Institute for Clinical Research and Health Policy Studies, Chief of the Division of Clinical Care Research, and Director of the Center for Cardiovascular Health Services Research at Tufts Medical Center. He is also Professor of Medicine at Tufts University School of Medicine and Director of its Graduate Program in Clinical and Translational Science at the Tufts Sackler School of Graduate Biomedical Sciences. His clinical practice is in the Pratt Diagnostic Clinic at Tufts Medical Center. In his research, Dr. Selker studies the factors that affect clinical care and its outcomes, and develops treatment strategies, decision aids, and computer-based systems for improving care. He is known for a series of studies of the factors influencing emergency cardiac care, including clinical, socioeconomic, and gender issues, and is particularly known for the development of cardiac “clinical predictive instruments.” These decision aids provide emergency physicians with predictions of their patients’ key outcomes, for real-time use in clinical care. Two of these, the ACI-TIPI (acute cardiac ischemia time-insensitive predictive instrument) and TPI (thrombolytic predictive instrument), are in electrocardiographs in use world-wide. He also is known for the development of information systems that provide the results of the ACI-TIPI and TPI as feedback to improve clinical care. In addition, Dr. Selker’s research includes work on fundamental issues of clinical study design, data analysis, and combination of clinical data and computer-based mathematical models that predict clinical outcomes. Dr. Selker is also an active teacher and mentor of clinical researchers. His PhD graduate program in clinical research in a biomedical graduate school was the first of its kind, and he has been involved nationally in the promotion of clinical research and clinical research training. He holds leadership roles in professional and scientific societies and serves on a variety of governmental and organizational committees and panels.
Program Director - Jonathan M. Davis, MD, joined Tufts Medical Center in June 2006 as Chief of Newborn Medicine and Professor of Pediatrics, after several years as Associate Chairman of Pediatrics, and Chairman of the IRB at Winthrop-University Hospital/SUNY Stonybrook School of Medicine in Mineola, New York. Dr. Davis’s recent research is on the delivery of antioxidant enzymes and genes to the neonatal lung. He is the first investigator to help develop a novel antioxidant protein in the laboratory and then bring the protein through animal studies and human trials, with dramatic improvements in neonatal outcome. Dr. Davis has a long history of NIH funding and has served on multiple committees for NHLBI and NICHD. His expertise in pediatrics and newborn medicine will broaden the scope of the CTRC and provide needed expertise for studies involving highly vulnerable subjects.
Associate Director– Tamsin A. Knox, MD, MPH, is an Associate Professor of Medicine at TUSM, and became Associate Program Director in 2004. Her primary role is the training and education of investigators and study coordinators. Dr. Knox is a gastroenterologist and hepatologist whose research focuses on nutritional and gastrointestinal aspects of HIV infection, including liver disease. She was a long-term co-director of the Nutrition for Healthy Living Study, a longitudinal cohort of more than 880 HIV-positive persons to determine the effects of nutritional status on the outcome of HIV infection. Dr. Knox currently studies cytochrome metabolism in HIV/HCV coinfected persons and serves as a co-director of the Tufts-Brown CFAR core on nutrition, metabolism, and gastrointestinal function. Dr. Knox was elected a Fellow of the American Gastroenterological Association in May 2007.
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