Edouard Vannier, PharmD, PhD
Assistant Professor, Division of Geographic Medicine & Infectious Diseases, Tufts Medical Center, Boston, MA
1985 - MS in Pharmacology - Universite Paris-Sud, Paris, France
1992 - PhD in Pharmacology - Universite Rene Descartes, Paris, France
1994 - PharmD - Universite Rene Descartes, Paris, France
Genetic architecture of host resistance to babesiosis
Immune requirements for resolution of babesiosis in susceptible hosts
Babesiosis is an infectious disease caused by protozoan parasites of the genus Babesia that invade and lyse red blood cells. In the United States, most cases of human babesiosis are caused by Babesia microti and occur in people beyond 50 years of age. Endemic areas include the Northeast and upper Midwest. Given the recent emergence of tick-borne and transfusion-transmitted babesiosis, babesiosis is now classified as a nationally notifiable disease.
Our research aims to identify and characterize the determinants of host resistance/susceptibility to Babesia microti infection. Our approach combines genetics and immunology. We are particularly interested to elucidate whether the age-acquired susceptibility to babesiosis results from the loss of determinants of resistance that are functionally prevalent in young age, or from the gain of determinants of susceptibility that become prevalent in old age. As for malaria, we anticipate that determinants of host resistance/susceptibility to babesiosis will pertain to the biology of red blood cells and to the mounting of an effective host immune response.
Learn more about Dr. Vannier's research in Babesiosis >
Vannier E, Krause PJ. Human babesiosis. N. Engl. J. Med. 366:2397-2407, 2012.
Vannier E, Gelfand JA. Babesiosis. In: Harrison’s Principles of Internal Medicine, 18th edition. DL Longo, AS Fauci, DL Kasper, SL Hauser, JL Jameson, J Loscalzo, eds. The McGraw-Hill Companies, Inc. 1706-1708, 2012.
Gelfand JA, Vannier E. Babesia species. In: Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 7th edition. GL Mandell, JE Bennett, R Dolin, eds. Churchill Livingstone. 3539-3545, 2009.
Krause PJ, Gewurz BE, Hill D, Marty FM, Vannier E, Foppa IM, Furman RR, Neuhaus E, Skowron G, Gupta S, McCalla C, Pesanti EL, Young M, Heiman D, Hsue G, Gelfand JA, Wormser GP, Dickason J, Bia FJ, Hartman B, Telford III SR, Christianson D, Dardick K, Coleman M, Girotto JE, Spielman A. Persistent and relapsing babesiosis in immunocompromised patients. Clin. Infect. Dis. 46:370-376, 2008.
Krause PJ, Daily J, Telford SR, Vannier E, Lantos P, Spielman A. Shared features in the pathobiology of babesiosis and malaria. Trends Parasitol. 23:605-610, 2007.
Borggraefe I, Yuan J, Telford SR, Menon S, Hunter R, Shah S, Spielman A, Gelfand JA, Wortis HH, Vannier E. Babesia microti primarily invades mature erythrocytes in mice. Infect. Immun. 74:3204-3212, 2006.
Vannier E, Borggraefe I, Telford SR, Menon S, Brauns T, Spielman A, Gelfand JA, Wortis HH. Age-associated decline in resistance to Babesia microti is genetically determined. J. Infect. Dis. 189:1721-1728, 2004
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