This study is for people who have a tear in their ear drum that has lasted longer than 3 months (chronic tympanic membrane perforation, or CTMP). It is looking at the ability of an investigational drug, ASP0598 Otic Solution, to close ear drum tears when given as ear drops. This study will consist of multiple arms, in which study participants will be randomly placed. Some participants will receive one dose of the study drug, some will receive multiple doses, and some will receive a placebo. Neither the participant nor the study team will know what was received.