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Role of EPA and DHA in fish oil on inflammation and lipid metabolism

Title Role of EPA and DHA in fish oil on inflammation and lipid metabolism
Therapeutic Area Cholesterol, Inflammation
Principal Investigator Stefania Lamon-Fava
Min Age 50 Years
Max Age 74 Years
Gender Both
Contact Kimberly Dupiton
More Information


Inflammation plays an important role in several chronic diseases including cardiovascular disease, diabetes mellitus, and neurodegenerative disorders. Fish oil, containing the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been shown to reduce the risk or severity of these diseases. While it is generally assumed that EPA and DHA have similar effects, evidence is emerging of different modes of action of EPA and DHA. The objective of this study is to assess the differential and common effects of EPA and DHA on inflammation and lipid metabolism.

Study Details

Inclusion Criteria

  • Triglycerides:90-500 mg/dL
  • Hs-CRP ≥2 mg/L
  • Hypertension or high serum glucose or belly fat

Exclusion Criteria

  • Taking fish oil supplements
  • Allergy to fish
  • Type 2 diabetes mellitus

Study Requirements

The study is conducted at the Jean Mayer USDA Human Nutrition Research Center on Aging. Participants will be asked to take fish oil capsules or placebo for about 34 weeks. The study will involve approximately 7 visits. Blood draw will be performed at every visit, in different amount at each visit and ranging from 30 mL to 120 mL (from 6 to 24 teaspoons, respectively).