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Match Study

Title Assessment of cellular and soluble mediators in contact lens discomfort and neuropathic corneal pain
Therapeutic Area Contact Lens Discomfort, Corneal Pain
Principal Investigator Pedram Hamrah, MD
Min Age 18 Years
Gender All
Contact Carly Satsuma
617 636-8665


The study will investigate the nerve changes and tear protein levels in contact lens users with and without symptoms of dry eye, and patients with contact lens intolerance, and compare these individuals with neuropathic corneal pain and normal non-contact lens users without symptoms.

Study Details

Inclusion Criteria

  • Willing and able to commit and consent to in vitro confocal microscopy
  • Daily contact lens wear experience and report a comfortable wearing time < 8 hours
  • Previous contact lens wear but stopped due to discomfort symptoms arising int he first 6 hours of lens wear.

Exclusion Criteria

  • History of ocular surgery or injury
  • History of diabetes
  • Use of topical or systemic anti-inflammatory therapy in the past 3 months

Study Requirements

1 visit lasting approximately 60-90 minutes, will undergo eye imaging in both eyes.