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Assessment of Coagulation Factors in Nonalcoholic Fatty Liver Disease (NAFLD) and Related Condition


Title Assessment of Coagulation Factors in Nonalcoholic Fatty Liver Disease (NAFLD) and Related Conditions
Therapeutic Area Diabetes Type 2, Liver Diseases, Healthy Volunteers
Principal Investigator Lidija Covic, Ph.D.
Min Age 18 Years
Gender Both
Contact Elizabeth Fltcher, PhD
617-636-8486

Overview

This non-interventional study seeks to determine the validity of the hypothesis that individuals with Nonalcoholic Fatty Liver Disease and/or its related conditions such as Type 2 Diabetes and obesity have elevated levels of two related coagulation proteins on their circulating blood cells, which are believed to play an important role in the development and progression of liver disease.

Study Details

Inclusion Criteria

  • Known diagnosis of NAFLD, Nonalcoholic Steatohepatitis (NASH), diabetes, hyperlipidemia, coronary artery disease, or metabolic syndrome.
  • Individuals without a known history of any of the above conditions (healthy controls).

Exclusion Criteria

  • Current or history of significant alcohol consumption for a period of more than 3 consecutive months within 1 year prior to screening
  • Autoimmune disorders, immunodeficiences, or HIV
  • All types of viral hepatitis, both chronic and acute

Study Requirements

The study requires a single blood draw of approximately 2 teaspoons, which will occur at the same time as blood is drawn for clinically indicated reasons. No separate visits to the hospital are required for research purposes. Participation in the study will conclude after completion of the blood draw.