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DCM Genetics Study

Title Dilated Cardiomyopathy Precision Medicine Study
Therapeutic Area Cardiac Failure, Cardiomyopathy, Cardiovascular Disease, Heart Failure
Principal Investigator Gordon Huggins, MD
Gender All
Contact Corinne Pellows
617 636 4884
More Information


The purpose of this study is to identify gene changes that cause DCM and gene differences that influence the development and severity of DCM. The genetic screening done for this study will be returned to the subject. These genetic studies may identify a change in a gene that has already been linked with DCM, a change in a gene not previously associated with DCM, or these studies may identify a gene or genes that affect the development and severity of the DCM. With this knowledge we hope to have a better understanding of how genes and gene changes cause DCM. We are collaborating with Dr. Ray Hershberger from The Ohio State University in the Dilated Cardiomyopathy (DCM) Precision Medicine Study, a family-based study aimed at enrolling individuals of European or African ancestry, and identifying the genes responsible for idiopathic DCM. Ours is one of several sites forming part of the DCM Consortium, a multi-institutional group established to conduct DCM research. This study requires one in person visit and a 10-15 minute phone call annually.

Study Details

Inclusion Criteria

  • A primary diagnosis of Dilated Cardiomyopathy, Family Cardiomyopathy, or Idiopathic Cardiomyopathy without known cause (except genetic)
  • EF <50%, Left Ventricular Ejection Fraction
  • European or African Ancestry

Exclusion Criteria

  • Coronary Artery Disease causing ischemic cardiomyopathy (>50% narrowing)
  • Primary Valvular Disease
  • Other forms or known cause of cardiomyopathy (e.g. hypertrophic, restrictive, arrythmogenic, sarcoid, amalyoid, drug induced, Adriamycin, etc.)

Study Requirements

Subjects will have 1 study visit, which takes about 2 hours, and a 20 min phone call visit (we will try to make the study visits coincide with their clinic visit). At the 1 study visit the following will be done:
  • Medical record review
  • Blood draw
  • Questionnaires