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Title A Phase III Randomized Trial of Lobectomy versus Sublobar Resection for Small (≤ 2 cm) Peripheral Non-Small Cell Lung Cancer
Therapeutic Area Lung Cancer
Principal Investigator Daniel Wiener, MD
Min Age 18 Years
Gender both
Contact George Mensing
More Information


The purpose of this study is to test a different way of doing surgery for lung cancer in subjects who have small tumors with no evidence of spread. Recent studies have questioned whether removing a larger portion of the lung containing the tumor offers much better control of the cancer than removing a smaller section of the lung. The purpose of this clinical trial is to look at whether removal of a small section of lung (called a sublobar resection) is equal to a lobectomy (a larger surgery which takes out an entire section or ‘lobe’ of the lung, or about one-quarter to one-half of one lung, depending on which lobe is taken out). This clinical trial will be studying the overall effects (good and/or bad) of a sublobar resection (smaller segment of your lung) compared to a lobectomy (entire lobe of your lung).

Study Details

Inclusion Criteria

  • Subjects with non-small cell lung cancer.
  • Subjects with otherwise normal organ function.

Exclusion Criteria

  • No subjects with complicating malignancies.
  • No subjects with prior radiation or chemotherapy for this cancer.

Study Requirements

Requires one visit prior to surgery and follow-up visits up to 7 years after surgery (total of 9 follow-up visits). Each follow-up visits will require a chest xray and CT scan.