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Development of the Neonatal Microbiome through Salivary and Stool Analyses
| Title |
Chronicling the Development of the Neonatal Microbiome through Salivary and Stool Analyses |
| Therapeutic Area |
Neonatal Necrotizing Enterocolitis, Neonatal Sepsis
|
| Principal Investigator |
Jill L. Maron, MD |
| Min Age |
0 Years |
| Gender |
All |
| Contact |
Shubham Bakshi, MD
617-636-5322
sbakshi@tuftsmedicalcenter.org
|
We will collect salivary and stool samples from newborns born in our NICU and obtain mRNA sequencing to identify microbial colonization. We will attempt to correlate aberrant colonization with adverse outcomes of newborn mortality and morbidities such as NEC and sepsis.
Inclusion Criteria
- Must be a patient in Tufts Medical Center’s Neonatal Intensive Care Unit (NICU).
Exclusion Criteria
- Newborns born with conditions and/or anomalies affecting gut and salivary microbiome;
- inpatients who are not NICU patients.
Study Requirements
on approximately ages 2 days, 4 days, 6 days, 8 days, 10 days and 12 days of life, a stool sample and a saliva sample will be collected. Saliva samples will be collected with a sterile syringe attached to low wall suction. Stool samples will be collected from the diaper.
