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RCT Comparing ESPB Solutions in Breast Surgery

Title An Investigator-Initiated, Double-Blind, Patient-Controlled, Randomized Control Trial Comparing the Effectiveness of Liposomal Bupivacaine to a Solution of Bupivacaine, Epinephrine, Clonidine, and Dexamethasone in Bilateral, Single Shot, Erector Spinae Plane Blocks during Oncoplastic Breast Surgery
Therapeutic Area Post-Operative Pain
Principal Investigator Sean W. Gallagher
Min Age 18 Years
Max Age 75 Years
Gender Femail
Contact Caroline Copacino


The purpose of this research is to find out if a local administration of liposomal bupivacaine works as well, or better, than our standard of care medication solution when administered in the same way to manage pain after surgery.

Study Details

Inclusion Criteria

  • Scheduled to undergo oncoplastic bilateral breast surgery at Tufts Medical Center

Exclusion Criteria

  • Adults unable to consent

Study Requirements

We expect that you will participate in this research study for 72 hours. You will be asked to describe your pain on both your right and left side separately 10 times over the course of 72 hours. There will be one phone call, approximately 15 minutes, at the end of the 72-hours. There will be no additional in person visits associated with this study.