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Retinal Abnormalities as Biomarker of Disease Progression and Early Diagnosis of Parkinson Disease


Title Retinal Abnormalities as Biomarker of Disease Progression and Early Diagnosis of Parkinson Disease
Therapeutic Area Parkinson's Disease
Principal Investigator Thomas Hedges, MD
Min Age 18 Years
Gender All
Contact Thomas Hedges, MD
617 636-5488
More Information https://clinicaltrials.gov/ct2/show/NCT02640339

Overview

The purpose of this study is:

  • To determine whether retinal abnormalities, as measured by high definition optical coherence tomography (HD-OCT) and visual electrophysiology techniques can be used as a clinical biomarker to monitor disease progression overtime in patients with Parkinson disease.
  • To establish whether these measures can be used to identify patients with PD in the premotor phase.
  • To define the rate of progression of retinal abnormalities in PD (both in the motor and premotor stages) for potential use as a clinical outcome measure

Study Details

Inclusion Criteria

  • Subjects with Parkinson Disease
  • Multiple System Atroph6y and Dementia with Lewy Bodies that fulfill current diagnostic criteria
  • Control subjects with no history of neurological or ophthalmological disorders

Exclusion Criteria

  • Subjects with glaucoma, retinopathy or significant media opacification (e.g., cataracts)
  • Subjects with a history of eye surgery or eye trauma
  • Inability to comply with the requirements of this study

Study Requirements

The study will consist of 7 study visits 6 months apart (during 3 years). All participants will be studied using spectral domain Optical Coherence Tomography to analyze their retinal structure