This study looks at how well an antibiotic prophylaxis, called levofloxacin, can prevent bacterial infection from developing in children and young adults receiving intensive cancer treatment or a stem cell transplant. The levofloxacin drug which prevents bacterial infection is experimental.
- Adequate renal function
- Adequate creatinine clearance level
- Patients with chronic active arthritis
- Females who are pregnant or breast feeding.
- Patients previously enrolled on the trial are not eligible.
Subjects receiving a stem cell transplant may be on this study for up to 60 days. If you are an acute leukemia subject you may be on this study for up to 2 chemotherapy cycles lasting up to 60 days each. The time will depend on how long it takes for your neutrophil count to recover or until your study doctor decides to treat you for a new suspected or proven infection. You will have follow-up examinations and medical tests at 2 and 12 months after treatment.