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Decidual Leukocytes Preterm birth and Preeclampsia

Title Role of decidual leukocytes and placental trophoblasts in the development of spontaneous preterm birth and preeclampsia 
Therapeutic Area High Blood Pressure in Pregnancy, Preterm Birth, Preeclampsia
Principal Investigator Errol Norwitz, MD, PhD, MBA
Min Age 18 Years
Max Age 45 Years
Gender Female
Contact Taysir Mahmoud
617-636-0766
tmahmoud@tuftsmedicalcenter.org

Overview

Understanding the etiology of preeclampsia and spontaneous preterm delivery through the characterization of placental trophoblasts and maternal decidual leukocytes as well as their interactions 

Study Details

Inclusion Criteria

  • Singleton pregnancy

Exclusion Criteria

  • Twin or multiple pregnancies;
  • Maternal Autoimmune disease;
  • HIV, Hepatitis B or Hepatitis C positive individuals 

Study Requirements

The study is a onetime maternal blood (25ml) and placental tissue donation with no clinical intervention or follow up and no interference with standard clinical care.