Back to Results


Title Environment, Epigenetics, Neurodevelopment and Health of Extremely Preterm Children
Therapeutic Area Premature Birth (Tufts Childrens Hospital), Premature Babies (Tufts Medical Center)
Principal Investigator Christina Sakai, MD
Min Age 15 Years
Gender All
Contact Yuxin Ma
617 636-4864


The purpose of this study is to study environmental risk factors and epigenetic processes as potential contributors to neurodevelopmental impairments in a group of individuals at very high risk by focusing on the relationship of prenatal exposure to placental inflammation markers and neonatal inflammation markers, the relationship of these inflammation markers to functional neuodevelopmental disorders and on the relationship of these markers to brain structural abnormalities.

Study Details

Inclusion Criteria

  • 15 years old
  • Previous participation in the ELGAN study

Exclusion Criteria

Study Requirements

One research visit at 15 years of age and second visit at 18 years of age. Each visit should last about 6 hours. Optional MRI scan at 15 year visit and optional blood draw (1 tablespoon) at 18 years visit.