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MAP Study


Title Molecular Assessment of the Consequences of Preterm Birth
Therapeutic Area Premature Birth (Floating), Preterm Birth
Principal Investigator Jill Maron, MD
Min Age 0 Years
Max Age 1 Years
Gender Both
Contact Vidya Iyer
617 636-0186

Overview

This study is being conducted to find out what genes are turned on or off (called "gene expression") in babies born preterm and how that may be related to complications of prematurity or other health conditions they may experience during or after their initial hospitalizations

Study Details

Inclusion Criteria

  • In Tufts Medical Center NICU

Exclusion Criteria

  • Infants born at 33 0/7 weeks gestational age or more
  • Infants born at another institution
  • Infants whose parents are unable to give consent for any reason

Study Requirements

We will collect 2.5-5.0 ml (one half to one teaspoon) of blood from the umbilical cord after the baby has been born and the cord clamped. This blood is normally discarded with the placenta. Please note that collection umbilical cord blood will not affect the birth or the health of the baby. We will isolate the RNA from the blood and study the baby's gene expression.

The baby's medical records will be reviewed for birth weight, gender, method of delivery (C-section or vaginal), and any medical conditions that occur during the initial hospital stay, for as long as the baby remains at Tufts Medical Center. If the infant is born at <28 weeks gestation, he/she will have neurodevelopmental follow-up assessments throughout the first three years of life at Tufts Medical Center as part of standard of care. This testing assesses the infant's developmental milestones and helps to ensure receipt of any additional support services needed. As part of this study, we will also review the baby's development at 18 months corrected age. "Corrected age" means when your infant would be 18 months old if he/she had not been born early. For example, infants born 2 months premature would have a chronological, or actual, age of 20 months old, but a corrected age of 18 moths. Pregnant women end their participation when the baby is born. The baby's participation lasts until discharge from Tufts Medical Center or until the end of developmental follow-up testing at 18 months corrected age at Tufts Medical Center.