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EGF Analysis in Patients with Plasma Cell Diseases


Title Epideermal Growth Factor (EGF) Analysis in Patients with Plasma Cell Diseases
Therapeutic Area Hematologic Disorders, Renal Disease
Principal Investigator Raymond Comenzo, MD
Min Age 18 Years
Max Age 99 Years
Gender Both
Contact Denis Toskic
617-636-5907

Overview

The purpose of this study is to perform interval urine analyses in patients with plasma cell diseases to determine if epidermal growth factor (EGF) can serve as a clinically useful indicator of kidney function over time in this patient population. This study will enroll 100 plasma cell disease patients over 2 years. No additional visits for this study are required. Patients will make interval donations of first morning urine samples that coordinate with standard follow-up clinic visits to Tufts Medical Center. The patient will bring their first morning urine to Tufts Medical Center in provided container, and the study team will bring the sample to the laboratory for EGF analysis.

Study Details

Inclusion Criteria

  • Patients with diagnoses plasma cell disease which include: solitary plasmacytoma, monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM), mutliple myeloma (MM), light chain amyloidosis (AL), POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes), Waldenstrom's Macroglobulinemia (WM), light chain deposition disease (LCDD) paraproteinemia, and heavy-chain disease.
  • Must be willing to make donations of first morning urine.

Exclusion Criteria

  • Patients who do not have a diagnoses plasma disease (including patients with non-AL amyloidosis).
  • Not willing to make donations of first morning urine

Study Requirements

Participants will be required to donate first morning urine samples at various intervals depending on their regular follow-up schedule. Participants will be provided with a urine container before each donation. and no donation will be required if the participant is not already planning a visit to Tufts Medical Center for standard of care reasons. No other procedures are required as part of this study.