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Autoreactive anergic B cells in Rheumatoid Arthritis

Title Pathogenic role of autoreactive anergic B cells in Rheumatoid Arthritis
Therapeutic Area Rheumatoid Arthritis
Principal Investigator Steven C. Vlad, MD, PhD
Min Age 45 Years
Max Age 65 Years
Gender All
Contact Vivian Deng
617 636-5727


The goal of the study is to determine the role of a particular type of white blood cell called immune cells in the development of Rheumatoid arthritis. Our study is focused on a specific type of immune cells (B lymphocytes) that circulate in the blood and normally provide protection against bacteria and viruses that cause diseases. However, sometimes the immune cells may get "confused" and will start attacking the body itself; this process is called autoimmunity. In Rheumatoid arthritis, the immune system (system in the body that protects the body against diseases) attacks joint tissue which resultsin joint stiffness, swelling and eventually leads to irreversible joint damage. This study plans to learn more about the reason why the immune system turns against the body's own joint tissue by separating immune cells from blood samples and carrying out biochemical tests on theses cells.

Study Details

Inclusion Criteria

  • Subjects who have confirmed (RF+/anti-CCP+) new diagnosis of Rheumatoid arthritis

Exclusion Criteria

  • Subjects without diagnosis of Rheumatoid arthritis
  • Subjects who have been treated with biologics (such as monoclonal antibody therapy and TNF-alpha inhibitors) within one year prior to study visit.

Study Requirements

There is no predetermined stop date. Tufts Medical Center will stop recruiting subjects when 28 subjects have been enrolled in the study. There is only a one time study visit during which a relatively small amount of blood (about 3 tablespoons or 50 mls) will be drawn from subjects.