Back to Results
Autoreactive anergic B cells in Rheumatoid Arthritis
||Pathogenic role of autoreactive anergic B cells in Rheumatoid Arthritis
||Steven C. Vlad, MD, PhD
The goal of the study is to determine the role of a particular type of white blood cell called immune cells in the development of Rheumatoid arthritis. Our study is focused on a specific type of immune cells (B lymphocytes) that circulate in the blood and normally provide protection against bacteria and viruses that cause diseases. However, sometimes the immune cells may get "confused" and will start attacking the body itself; this process is called autoimmunity. In Rheumatoid arthritis, the immune system (system in the body that protects the body against diseases) attacks joint tissue which resultsin joint stiffness, swelling and eventually leads to irreversible joint damage. This study plans to learn more about the reason why the immune system turns against the body's own joint tissue by separating immune cells from blood samples and carrying out biochemical tests on theses cells.
- Subjects who have confirmed (RF+/anti-CCP+) new diagnosis of Rheumatoid arthritis
- Subjects without diagnosis of Rheumatoid arthritis
- Subjects who have been treated with biologics (such as monoclonal antibody therapy and TNF-alpha inhibitors) within one year prior to study visit.
There is no predetermined stop date. Tufts Medical Center will stop recruiting subjects when 28 subjects have been enrolled in the study. There is only a one time study visit during which a relatively small amount of blood (about 3 tablespoons or 50 mls) will be drawn from subjects.