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Zoster Eye Disease Study (ZEDS)

Title Long-term Suppressive Valacyclovir Treatment for Herpes Zoster Ophthalmicus
Therapeutic Area Herpes Zoster
Principal Investigator Kenneth Kenyon, MD
Min Age 18 Years
Gender Any
Contact Carly Satsuma
More Information


This study is a double-masked, placebo controlled randomized clinical trial looking to find out whether one year of a low dose of the medicine valacyclovir reduces complications of shingles affecting the eye.

Study Details

Inclusion Criteria

  • Ability to take oral medication and willing to adhere to study medication regimen
  • Diagnosed with Herpes Zoster Ophthalmicus (HZO) in one eye with V1 distribution and documented history within 1 year of enrollment of either dendritiform epithelial keratitis (DEK), stromal keratitis (SK), endothelial keratitis (EK), or iritis (IR

Exclusion Criteria

  • History of immunocompromised status
  • Renal insufficiency
  • Allergy or adverse reaction to valcyclovir or acyclovi

Study Requirements

8 study visits over the span of 18-21 months. 5 blood collections of approximately 2 teaspoons each time.