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Zoster Eye Disease Study (ZEDS)
This study is a double-masked, placebo controlled randomized clinical trial looking to find out whether one year of a low dose of the medicine valacyclovir reduces complications of shingles affecting the eye.
- Ability to take oral medication and willing to adhere to study medication regimen
- Diagnosed with Herpes Zoster Ophthalmicus (HZO) in one eye with V1 distribution and documented history within 1 year of enrollment of either dendritiform epithelial keratitis (DEK), stromal keratitis (SK), endothelial keratitis (EK), or iritis (IR
- History of immunocompromised status
- Renal insufficiency
- Allergy or adverse reaction to valcyclovir or acyclovi
8 study visits over the span of 18-21 months. 5 blood collections of approximately 2 teaspoons each time.