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Post-COVID-19 Recovery

Title The Utility of X-Ray Velocimetry Analysis in Assessing the Ventilatory Limitations in Individuals with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Therapeutic Area Covid-19
Principal Investigator Mahe Ghamloush, MD; Nicholas Hill, MD
Min Age 18 Years
Gender Any
Contact Gail Pires


The purpose of the study is to learn about the problems that some individuals who recover from a COVID-19 infection continue to have months after they recover from the initial phase of the infection. We will be performing specific type of imaging called x-ray velocimetry. This allows us to understand regional lung ventilation. We will be examining if the measures of regional lung ventilation are more abnormal in participants who have previously had COVID-19 compared to those who have not previously acquired this infection. We will also investigate if the measurements obtained from x-ray velocimetry correlate with ratings of certain symptoms, quality of life ratings, and results of pulmonary function test and a walking test. 

The study includes 1 study visit and will be performed at Tufts Medical Center in Boston, MA.

We expect up to 48 participants will be enrolled in this study at Tufts Medical Center in order to have 40 participants complete the study.  

Study Details

Inclusion Criteria

For main cohort:

  • Documented SARS-CoV-2 infection by RT-PCR or Antigen testing more than 3 months ago
  • Persistent symptoms of chronic fatigue, shortness of breath or exercise tolerance of unclear etiology

For comparison cohorts:

  • Documented SARS-CoV-2 infection by RT-PCR or Antigen testing more than 3 months ago
  • OR no previous suspect or confirmed SARS-CoV-2 infection
  • Absence of symptoms of chronic fatigue, dyspnea or exercise intolerance

Exclusion Criteria

  • Pregnancy
  • Active malignancy undergoing treatment or with suspected or confirmed involvement of the lung
  • Unable to perform pulmonary function tests

Study Requirements

1 online questionnaire and 1 study visit which includes collection of medical history, Quality of Life Questionnaires, Pulmonary Function Tests (PFTs), 6 Minute Walk Test, Chest CT scan, X-Ray Velocimetry imaging.