TXA Epi Study

This is a multisite, randomized controlled clinical trial evaluating the effect of local tranexamic acid on post-operative ecchymosis in eyelid surgery. Patients will act as their own controls with one eyelid receiving a control injection of standard local anesthetic whereas the other eyelid will be randomized to receive a mixture of local anesthetic and tranexamic acid. Post-operative ecchymosis will be graded by a masked reviewer using a validated scale.

Inclusion Criteria

1. any patient >18 years of age < 85 years of age
2. have consented for upper/lower eyelid blepharoplasty (both cosmetic and/or functional)
3. additional co-current forehead/brow or upper/lower eyelid surgeries may be included

Exclusion Criteria

1. systolic BP > 180 on day of surgery
2. patients who are currently pregnant
3. anticoagulant/antiplatelet use within 7 days of surgery

Study Requirements

Patients will require at least 4 visits, 3 of which will be office visits and 1 will be for the surgery. All of these clinical encounters are necessary for the surgical evaluation and post-operative management of eyelid surgeries and therefore do not occur as stand-alone research visits. Patients will participate in the study up to 1 month after surgery, which is the last post-operative follow up visit. Only photographs will be taken pre- and post- surgery, which is part of the standard of care. No blood or tissue collection will be needed. No additional imaging studies are needed.