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The Tick Study

Title A Phase 2a, Randomized, Double-Blind, Placebo-Controlled, Single-Center, Human Tick Kill Proof-of-Concept Study Evaluating the Safety, Tolerability, and Whole Blood Concentration of TP-05 (lotilaner) in Healthy Volunteers
Therapeutic Area Healthy Volunteers
Principal Investigator Yoav Golan, MD and Linden Hu, MD, PhD
Min Age 18 Years
Max Age 59 Years
Gender Any
More Information


Researchers at Tuft Medical Center are looking for healthy volunteers to join a study of an investigational drug that may kill ticks and prevent Lyme disease. 

Study Details

Inclusion Criteria

Between 18 to 59 years old.

Exclusion Criteria

Have a history of severe reactions to tick bites.

Currently pregnant or trying to conceive.

Study Requirements

Participants will take one dose of the study drug or a placebo. There will be 10 visits to Tufts Medical Center over the course of up to 301 days. Ticks will be placed on your arm twice during the study to test the drug's effectiveness. The ticks are lab-grown and extensively tested for diseases. Qualified participants who complete all study visits will receive compensation of $3,000