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The Tick Study

Title A Phase 2a, Randomized, Double-Blind, Placebo-Controlled, Single-Center, Human Tick Kill Proof-of-Concept Study Evaluating the Safety, Tolerability, and Whole Blood Concentration of TP-05 (lotilaner) in Healthy Volunteers
Therapeutic Area Healthy Volunteers
Principal Investigator Yoav Golan, MD and Linden Hu, MD, PhD
Min Age 18 Years
Max Age 59 Years
Gender Any
Contact Rupali Ranade, MBBS
More Information


Researchers at Tuft Medical Center are seeking healthy volunteers to participate in a study of an investigational drug that may prevent tick bites. 

Study Details

Inclusion Criteria

Between 18 to 59 years old.

Exclusion Criteria

Have a history of severe reactions to tick bites.

Currently pregnant or trying to conceive.

Study Requirements

The study involves a single dose of a human version of an investigational drug currently approved to prevent tick bites in dogs or a placebo.  

Participation will involve 10 visits to Tufts Medical Center over the course of 301 days. 

Laboratory raised ticks, tested to be free of all known human diseases will be placed on your arm in a sealed dressing twice during the study to test the ability of the drug to prevent tick bites. 

Compensation: Qualified participants who complete all study visits will receive compensation up to $2,450.