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Screening for AL Amyloidosis in SMM
| Title |
Screening for AL Amyloidosis in Smoldering Multiple Myeloma |
| Therapeutic Area |
Multiple Myeloma
|
| Principal Investigator |
Raymond Comenzo, MD |
| Min Age |
40 Years |
| Gender |
Any |
| Contact |
Latoya Lashley
617-636-3264
ncccr@tuftsmedicalcenter.org
|
In response to the significant need to intensify efforts at early diagnosis, this trial proposes further building on knowledge of the genetic basis of AL in clonal plasma cells. The main goal of this study is to screen for the diagnosis of light-chain amyloidosis (AL) before the onset of symptomatic disease.
Inclusion Criteria
Patients 40 years of age and older diagnosed with )SMM with dFLC greater than 23 mg/L and abnormal κ::λ FLC ratio
Exclusion Criteria
Patients with MGUS or with a previous finding of amyloid in other biopsies will not be included. Patients younger than 40 years of age are not eligible.
Study Requirements
One-time donation of bone marrow and peripheral blood samples.
