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Relationship Between Protein Intake and ICU Skeletal Muscle Weakness

Title Relationship between Protein intake and ICU Skeletal muscle weakness
Therapeutic Area Muscle Disorders
Principal Investigator Pavan Sekhar
Min Age 18 Years
Max Age 50 Years
Gender Any
Contact Hanan Elkalawy


Evaluate the correlation between ICU Skeletal muscle loss and protein intake and investigate the lack of daily protein intake by the presence of loss of rectus femoris muscle quantity and quality.

Study Details

Inclusion Criteria

 1- Glasgow Coma Scale ≤ 8 and an injury severity score (ISS>15) were admitted to our ICU within 24 hours after the injury. 
2- only well-nourished ( Modified Nutric –Score for Risk Screening = 0- 4), previously healthy subjects will be recruited

Exclusion Criteria

1- Pregnancy, 
2- prior mobility disorder or comorbidities that severly affect the body system  
3- on drugs affect the muscle including Prolonged corticosteroids (CS) and/ or neuromuscular blocking agents (NMBA) use  

Study Requirements

We expect that you will be in this research study for five days. The research subject's Rectus femurs muscle will be assessed by Ultrasound machine to see the muscle size and colour on the day 0, 1st and 5th days.and blood sample will be collected for three days for serum albumin and blood urea nitrogen at day 0, 1st and 5th days.