Profiling single-cell signatures in patient nasal samples with and without treatment.

Patients suffering from chronic rhinosinusitis (CRS) with polyps (CRSwNP) may be offered pre-operation treatments. While the gross effect of some of these treatments, such as prednisone have been investigated at a gross, cell population level, these studies are generally focused on a subset of the cells found in the tissue, often solely the immune cells. The effect of these treatments on the tissue as a whole, including the underappreciated complexity of the epithelium itself, is a major gap in current knowledge. We are proposing to collect discarded polyp tissue following resection in patients suffering from chronic rhinosinusitis with and without these treatments to determine specific effects these treatments may be having on distinct cell types.

Inclusion Criteria

1. Patients with symptomatic chronic rhinosinusitis with nasal polyps (CRSwNP) aged 18 years and older who failed appropriate medical therapy and elected to proceed with endoscopic sinus surgery

Exclusion Criteria

1.Patients with an immunodeficiency disorder, cystic fibrosis, or primary cilliary dyskinesia

2.Patients with either antrochoanal or unilateral polyps

Study Requirements

Collection of discarded, surgically removed tissue.