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Cervix Disorders


Cervical Stiffness Measurement in Cervical Insufficiency

The purpose of the study is to measure the softness of the cervix.  The softness of the cervix will be compared in two groups of pregnant women.  One group is women who will be having a surgery to strengthen the cervix (a cerclage surgery).  The second group is normal women in the prenatal clinic.  We anticipate recruiting 140 patients total (60 cases and 80 control patients.)

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Neonatal Abstinence Syndrome


Hypothalamic Dysregulation and Oral Feeding in Neonates with Prenatal Drug Exposure

This pilot study is aimed at furthering our understanding of prototypical feeding behaviors in newborns born to mothers who used opiates and/or cannabinoids during pregnancy. It is well known that infants born drug-exposed may struggle with their oral feeding skills or may consume 20-40% more calories per day than infants who were not drug exposed during gestation. Our understanding of the molecular mechanisms involved in these feeding behaviors is poorly understood. By comparing the salivary expression of key hypothalamic regulatory genes and/or proteins known to be assoicated with feeding and reward behaviors between drug and non-drug exposed newborns, we hoped to elucidate biological mechanisms responsible for aberrent feeding behaviors.

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Neonatal Opioid Withdrawal Syndrome


Hypothalamic Dysregulation and Oral Feeding in Neonates with Prenatal Drug Exposure

This pilot study is aimed at furthering our understanding of prototypical feeding behaviors in newborns born to mothers who used opiates and/or cannabinoids during pregnancy. It is well known that infants born drug-exposed may struggle with their oral feeding skills or may consume 20-40% more calories per day than infants who were not drug exposed during gestation. Our understanding of the molecular mechanisms involved in these feeding behaviors is poorly understood. By comparing the salivary expression of key hypothalamic regulatory genes and/or proteins known to be assoicated with feeding and reward behaviors between drug and non-drug exposed newborns, we hoped to elucidate biological mechanisms responsible for aberrent feeding behaviors.

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Obesity


Lifestyle Intervention in Preparation for Pregnancy (LIPP)

The aim of this study is to improve the metabolic health of overweight and obese women prior to a planned pregnancy. 

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Pregnancy


Produce Prescriptions on Maternal and Birth Outcomes: A Food is Medicine Intervention among Pregnant Women-1

 

 

This study assesses if it is possible to provide produce as a prescription in prenatal clinical care for pregnant women and to understand the impact that may have on their health and the health of their newborns after delivery. 

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Glycemic Outcomes and Metabolic Observations in Mothers and Offspring

GO MOMS is a study that tracks maternal blood sugar levels in pregnancy and how the levels may predict the development of gestational diabetes (pregnancy-related high blood sugar) or relate to the size of a baby at birth. As not enough is known about who will get gestational diabetes and because treatment of gestational diabetes in later pregnancy does not make all of the complications go away, learning about the early pregnancy blood sugars may help us learn how to improve prenatal care in the future for healthier families. 

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Cervical Stiffness Measurement in Cervical Insufficiency

The purpose of the study is to measure the softness of the cervix.  The softness of the cervix will be compared in two groups of pregnant women.  One group is women who will be having a surgery to strengthen the cervix (a cerclage surgery).  The second group is normal women in the prenatal clinic.  We anticipate recruiting 140 patients total (60 cases and 80 control patients.)

More

Lifestyle Intervention in Preparation for Pregnancy (LIPP)

The aim of this study is to improve the metabolic health of overweight and obese women prior to a planned pregnancy. 

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Maternal lipid metabolism and placental function in early pregnancy

The purpose of this study is to measure the effect of maternal metabolism (how your body uses food for energy) on the growth of the placenta (afterbirth), and how the placenta uses lipids.

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Maternal Metabolic Mediators of infant Adiposity (MaMMA)

The purpose of this study is to measure the effect of maternal diet and metabolism (how your body uses food for energy) on the growth of the baby, and how the placenta uses lipids.

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Placental function in early pregnancy

This study will determine how the placenta is affected by glucose in early pregnancy.

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Vision Health


Single-Center Baseline Data on Vision Health in Infants with History of Prenatal Drug Exposure

This study will evaluate infant vision health based on the history of prenatal drug exposure. Data from this study will be used to create a new process which will include vision health as part of the discharge planning for infants with prenatal drug exposure admitted to Tufts Children’s Hospital

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