The purpose of this study is to determine if the study drug, BMS-986141, is safe and prevents a future stroke when given daily to subjects who have experienced acute ischemic stroke or transient ischemic attack (TIA) and are also taking acetylsalicylic acid (also known as aspirin or ASA).
- Acute ischemis stroke or high-risk TIA
- Enrolled within 48 hours after onset of symptoms
- Able to tolerate ASA at a dose from 75 to 162 mg/day
- Any history of atrial fibrillation (Afib)
- Any condition requiring ongoing treatment with an anticoagulant
- Planned or anticipated invasive surgery or procedure during study duration
Subjects will undergo 90 days of treatment with BMS-986141 and Aspirin followed by a 120 day follow-up. Subjects will undergo assessments at Day 1, Day of Discharge, Day 10, Day 28, Day 56, Day 90 and Day 120. Subject will undergo blood draws 5 times during Day 1 and twice on Day 28. Additional laboratory tests will take place on Day 1, Day of Discharge, Day 28, Day 56 and Day 90. The total blood volume collected during the whole study will be approximately 230 ml (~15.5 tablespoons). Subject will receive a study-specific MRI on Day 1 and Day 28.
Number of research visits: 8 visits
Length of participation: 120 Days
Assessments: Physical exam, vital signs, MRI, ECG, platelet aggregation, PK sampling, hematology, urinalysis, clinical chemistry