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Fetal MRI study of Twin-Twin Transfusion Syndrome

Title Evolution of Cerebral Development in Twin-Twin Transfusion Syndrome (TTTS)
Therapeutic Area Twin-Twin Transfusion Syndrome
Principal Investigator Tomo Tarui
Gender Both
Contact Vidya Iyer


The study includes 30 pregnant women with twin pregnancy - 15 carrying twin fetuses that have been prenatally diagnosed with twin-twin transfusion syndrome (TTTS), and 15 carrying healthy twin fetuses. These women may be offered a fetal MRI scan at no cost to the women. Dr. Tarui will look for differences and changes in the fetal brains with TTTS compared to unaffected twin fetuses.

The study also includes children of women who participate in the study. Children will be followed up after the birth and their neurodevelopmental outcome will be precisely recorded by battery of neurodevelopmental testing at 18 month of age.

The study’s goal is to establish anatomical landmarks for fetal brain development in TTTS that can subsequently predict future neurodevelopmental outcome of affected children.

Study Details

Inclusion Criteria

  • Pregnant women with identical twin pregnancy
  • Pregnant women with twin pregnancy diagnosed with twin-twin transfusion syndrome

Exclusion Criteria

  • Fetus/infant with other major malformation such as congenital heart disease.
  • Fetus/infant with chromosomal anomalies or known genetic disorders

Study Requirements

One (or two) fetal MRI study (~2h) at no cost