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TLR function on alveolar macrophages is altered in the elderly

Title TLR function on alveolar macrophages is altered in the elderly
Therapeutic Area Healthy Volunteers
Principal Investigator Alexander Panda, MD, PhD, MPH
Min Age 21 Years
Gender All
Contact Alexander Panda, MD, PhD, MPH
203 216 4653


Perform a pilot study to establish the average and standard deviations from experimental readouts reflective of TLR function in human alveolar macrophages (AM) collected from healthy young and old people.

Study Details

Inclusion Criteria

  • Age 21-30 or 65 and older

Exclusion Criteria

  • Use of medication, such as warfarin, Coumadin, immunosuppressants, or antibiotics within the past 2 weeks.
  • Evidence of acute infection, identified or symptoms such as: fever, chills, night sweats, nausea, diarrhea, cough, muscle pain, headaches in the past 2 weeks.
  • Treatment for cancer in past 3 months

Study Requirements

The first visit will take place at participants house/apartment, the Beverly Council of Aging, the Sterling YMCA in Beverly, the Primary Care Clinics at Tufts Medical Center or the Human Nutrition Research Center on Aging (HNRCA) depending on preference. If eligible and deciding to join the study we will ask some questions about participants health. This will take about 15 minutes in total, then we will collect approximately 6 tablesppons of blood.

During the second visit we will perform the bronchoscopy. The bronchoscopy procedure will be conducted in the Bronchoscopy Suite at Tufts Medical Center. Participants will have to arrive 1 hour prior to the procedure. The whole procedure will take about 30 minutes, and participants will have to stay another 30 to 90 minutes on campus for observation before allowed to go home (total time commitment up to e3 hours.)