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BK in OHT


Title Evaluation of BK Virus Reactivation and Kidney Disease in Heart Transplant Recipients
Therapeutic Area Heart Transplantation
Principal Investigator Natalie Nierenberg, MD
Min Age 18 Years
Gender All
Contact Natalie Nierenberg
617 636-7761

Overview

BK virus reactivation and disease is emerging as an important cause of allograft dysfunction and loos, and the incidence of BKV reactivation and disease appears to be rising. This has been attributed to the recent us of newer, highly potent immunosuppressive agents. Little is known about the biologic behavior of the virus after reactivation and it progression to disease in heart transplant recipients. We aim to describe the prevalence of BK reactivation in urine and plasma samples of 100 pilot patients to begin to elucidate these gaps in our knowledge that may impact morbidity and mortality following heart transplantation.

Study Details

Inclusion Criteria

  • Heart transplant patients aged 18 years or older who receive their post-transplant care exclusively at Tufts Medical Center.

Exclusion Criteria

  • Dialysis dependence
  • Combined heart-kidney transplantation
  • Physical or cognitive impairment which would prevent provision of informed consent.

Study Requirements

Single visit with one blood collection (single tube) and one urine collection (2-5mL).