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International PFO Consortium

Title Secondary Stroke Prevention in Patients with Patent Foramen Ovale: The International PFO-Consortium
Therapeutic Area Stroke
Principal Investigator David E. Thaler, MD, PhD
Min Age 18 Years
Gender Both
Contact Haley Huggins
More Information


The purpose of this study is to learn more about how often people with PFOs have a second stroke after having the first one. This registry will investigate the impact of age, blood thinning drugs (such as aspirin and Coumadin), and closure of the PFO on the risk of stroke.

Study Details

Inclusion Criteria

  • Men and women older than 18 years with ischemic stroke or TIA within the previous 3 months
  • Diagnosis of PFO established by transesophageal echocardiography (TEE)
  • Informed consent

Exclusion Criteria

  • History of brain bleeding and/or aneurysm
  • Contraindications for TEE or iodine
  • Pregnancy

Study Requirements

Information about the patient’s health will be collected every 12 months for up to 3 years. If the patient does not have a scheduled visit with their doctor at that time, they will be contacted by telephone to provide the information.