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clinical trial
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This trial has two parts. Part A, an initial non-randomized Safety Run-In Phase to confirm the safety and tolerability at the selected dose range level of BNT113 in combination with pembrolizumab. Part B, the Randomized Phase of BNT113 in combination with pembrolizumab versus pembrolizumab monotherapy to generate pivotal efficacy and safety data in the first line setting in patients with unresectable recurrent or metastatic HPV16+ HNSCC expressing PD-L1 with CPS ≥1. Randomization will be stratified by PDL1 CPS <20 vs PD-L1 CPS ≥20, and prior chemotherapy (yes vs no).
Medical building
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Working closely together, our clinical teams care for patients from birth through their late teenage years.  At Tufts Medical Center in Boston, we strive to keep the children and adolescents of our community healthy by providing routine primary care as well as emergency care and day surgery. 
Medical building
Hospital
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Originally founded in 1893, we are a 234-bed general hospital offering a wide range of services, including expert cardiac care, 24-hour emergency care, wound care management and maternity services with an on-site Level II Special Care Nursery. We are the only hospital in the area offering an emergency cardiac catheterization lab, a life-saving procedure to open blocked arteries and limit heart damage. We are supported by over 700 affiliated physicians and have access to advanced specialty care with our clinical affiliation with Tufts Medical Center. 
Hospital
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If you or a loved one is entering the final chapter of their life, you can count on our hospice care team to deliver the comfort, dignity and peace that you deserve—either within our doors or at home. ...
Service
Did you know that a vascular anomaly is when there is an unusual development of blood vessels? Sometimes you can see them as birthmarks, but in other cases, doctors need to use imaging tests to spot them. ...
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The Buchsbaum Laboratory focuses on studying signal transduction pathways underlying cancer cell growth and metastasis. In particular, we are interested in pathways involving the Rac protein, a member of the Ras superfamily that is a central player in multiple signaling pathways affecting malignant cell behavior.
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Our faculty actively participates in clinical and basic sciences research on urological oncology, benign prostate hyperplasia (BHP) and minimally invasive surgical procedures. Basic laboratory research is focused on prostate cancer and BPH.
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The Miaofen Hu laboratory is studying the role of CDK6 in Notch-mediated stem cell transformation and leukemogenesis.
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The MCRI sponsors Multidisciplinary Research Groups that foster collaboration among clinical, translational and basic scientists including MCRI faculty and investigators across Tufts Medicine and Tufts University. These groups include the Cardio-Oncology Research Group, the Cardio-Renal Research Group, the Vasculo-Neuro Research Group, the Women’s Cardiovascular Health Research Group, and the Wound Healing Research Group.
Pharmacy
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Managing treatment made easy

Tufts Medicine Specialty Pharmacy is here to help you manage your disease and the specialty medications used to treat it. We provide you with services beyond just filling your prescriptions. We will guide you through your treatment plan and work with you and your doctors to achieve the best possible treatment outcome. We use the most current treatment information for common conditions, diagnoses, diagnostic procedures and medical interventions to ensure safe and effective drug therapy.
Pharmacy