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The cornea (window in the front of your eye) is made up of many nerves with important regions that allow you to feel sensations like, heat, cold, pressure and vibration. It is well known that many ocular surface disorders, such as dry eye disease (DED), neurotrophic keratitis and post-herpetic neuralgia, affect corneal nerve structure, which can be detected by a special type of eye imaging called ‘In-vivo Confocal Microscopy (IVCM)’. However, the relationship between eye symptoms, signs and abnormal corneal nerve functions are not yet well understood.

Multi-center, observational post-approval registry to compare patient and graft survival of adult primary heart transplant recipients receiving DBD donor hearts perfused and assessed on the OCS Heart System compared to adult recipients of DBD donor hearts preserved using ischemic cold storage hearts (Control) at the same Registry centers over the same time period. The objective of this post-approval registry is to provide additional real-world evidence of the performance of the OCS Heart System to preserve DBD donor hearts.

We propose to develop an economic in-office pain tests that may help screen and differentiate patients with neuropathic corneal pain (NCP) that could be used at any ophthalmic office. These five in-office pain tests include response with filter glasses, moisture googles, cold saline, hypertonic saline and topical proparcaine.