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The Kapur Lab focuses on molecular mechanisms of cardiac remodeling and myocardial recovery. The laboratory has generated novel insight into signaling via the transforming growth factor beta (TGFb) family with a particular focus on the TGFb co-receptor endoglin (CD105) and Bone Morphogenetic Protein 9 (BMP9). The lab’s translational research focuses on preclinical models of acute and chronic heart failure, invasive hemodynamics, circulatory support device development, and cardioprotective mechanisms in the setting of acute myocardial infarction.

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The Tufts Medicine-Affiliated Hospitals Orthopaedic Residency Program is a 5-year, ACGME-accredited program that provides exceptional training in the operative and non-operative management of musculoskeletal injury and diseases. We accept four candidates into the program each year through the National Residency Matching Program (NRMP).

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Physician-researchers in the Tufts Medical Center William B. Schwartz Division of Nephrology lead the way in conducting clinical research to define chronic kidney disease and have written the guidelines for its medical management.

The MCRI Mouse Physiology Core Laboratory is dedicated to the application of whole-animal models to pursue questions related to the pathophysiology of cardiovascular disease. The MCRI has established a series of cardiovascular models in rodents that are in active use in both the MCRI and in laboratories around the U.S. and the world. Models developed at the MCRI include a mouse model of carotid injury; chronic myocardial infarction, transverse aortic constriction and others. Phenotyping methods developed at the MCRI Mouse Core include a closed chest electrophysiology catheter-based procedure and dual ventricular pressure volume loop recording among others. The Mouse Core also routinely performs standard disease models and phenotyping assays relevant to cardiac and vascular physiology, including models of ventricular pressure overload, left and right ventricular pressure-volume loop analysis, cardiac echocardiography, telemetry implantation for blood pressure and ECG monitoring and many others.

The 2-year Clinical Track is designed to orient fellows towards careers in clinical nephrology. Drawing on the strengths of Tufts Medical Center as both a quaternary-care referral center and a community resource, fellows are exposed to the spectrum of nephrology consultations including acute kidney injury, electrolyte and acid/base disorders, chronic kidney disease, and dialysis.

Department of Surgery

The Jaffe laboratory is focused on understanding the molecular mechanisms by which blood vessels become dysfunctional to lead to common cardiovascular conditions, including heart attack, stroke, high blood pressure, in-stent restenosis, vein graft failure and heart failure. We are interested in understanding how traditional risk factors like aging, obesity, high blood pressure or high cholesterol, or new risk factors like novel cancer treatments, cause blood vessels to become diseased. We are also focused on understanding sex differences in how these cardiovascular diseases develop, in order to identify sex-specific precision medicine strategies.

Dr. Werner's research focuses on using pregnancy as a stress test to identify life-long disease risk.