Endocrinology, Diabetes and Metabolism

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Anastassios G. Pittas, MD, MS Accepting New Patients Virtual Appointments Available


Programs + Specialties
Training + Education Cornell University Medical College; New York Presbyterian Hospital; Tufts Medical Center
Board Certifications Endocrinology, Diabetes and Metabolism
NPI # 1508976036
Gender Male
Language(s) Greek
Accepted Insurances View Accepted Insurances at Tufts MC + Tufts Children's Hospital

The Patient Rating score is an average of all responses to physician-related questions on our nationally-recognized Patient Satisfaction Survey

Tufts Medical Center
Biewend Building, 2nd Floor
800 Washington St.
Box 268
Boston, MA 02111
Phone #: 617-636-5689
Fax #: 617-636-4719

• 2021, 2020, 2019, 2018/2017, 2016 "Top Doctor," Boston Magazine
• 2021, 2020, 2019, Cigna Care Designated and Tier 1 Physician. This designation is given to physicians in the highest group for quality measures and cost efficiency.
• 2017, Biomedical Research Exemplar Award, which honors individuals doing high-quality, high-impact, federally-funded research who also maintain an impressive reputation for professionalism and integrity in their work.
• 2017, The Donna Seto-Young Award, which recognizes meritorious achievement in the advancement of science, education, practice of medicine or improvement of human health and well-being.
• 2016, "Top Doctor," Boston Magazine
• 2014 - 2015, Chair (Standing), NIH Study Section - Clinical & Integrative Diabetes and Obesity
• 2011 - 2014, Member (Standing), NIH Study Section - Clinical & Integrative Diabetes and Obesity
• 2012, Robert M. Russell Scientific Achievement Award, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
• 2009 The Blaise Widmer Distinguished Lectureship in Nephrology, "The Role of Vitamin D in Cardiometabolic Disease"
• 2000 The Dr. Gerald J. and Dorothy R. Friedman Foundation Scholar, Tufts Medical Center
• 1999, 2007, Oliver Smith Award Tufts Medical Center, given in recognition of excellence, compassion and extraordinary and thoughtful care and service to patients, Tufts Medical Center, Boston MA

Below are representative publications. A complete list of publications can be found at https://agpittas.com/publications.

Dawson-Hughes B, Staten M, Knowler WC, Nelson J, Vickery EM, LeBlanc ES, Neff LM, Park J and Pittas AG. Intratrial Exposure to Vitamin D and New-Onset Diabetes Among Adults With Prediabetes: A Secondary Analysis From the Vitamin D and Type 2 Diabetes (D2d) Study. Diabetes Care 2020 Pittas AG, Jorde R, Kawahara T, Dawson-Hughes B. Vitamin D Supplementation for Prevention of Type 2 Diabetes Mellitus: To D or Not to D? J Clin Endocrinol Metab. 2020 Dec 1;105(12)

Pittas AG and Balk EM. Untangling the Gordian Knot of vitamin D supplementation and type 2 diabetes prevention Diabetes Care 2020

Angellotti E, Muppavarapu S, Siegel R and Pittas AG. The calculation of the glucose management indicator (GMI) is influenced by the continuous glucose monitoring system and patient race. Diabetes Technology and Therapeutics 2019 Dec 31. PMID:3182101

Delichatsios HK and Pittas AG Integrating Nutrition Education into Clinical Practice. Nestle Nutr Inst Workshop Ser. 2019;92:171-182. doi: 10.1159/000499560. Epub 2019 Nov 28

Pittas AG, Dawson-Hughes B, Sheehan P, Ware JH, Knowler WC, Aroda VR et al. Vitamin D supplementation and prevention of type 2 diabetes. N Engl J Med 2019 Aug 8:381(6):520-530. PMID:31173679

Angellotti E, Wong JB, Pierce A, Hescott B and Pittas AG. Combining Wireless Technology and Behavioral Economics to Engage Patients (WiBEEP) with cardiometabolic disease: a pilot study. Pilot Feasibility Stud. 2019 Jan 15;15:5;

Shahraz S, Pittas AG, Thomas C, Saadati M and Kent D. Change in testing, awareness of HbA1c levels, and glycemic control in US adults, 2007-2014. JAMA 2017 Nov 14;318(18):1825-1827

Lewis MR, Macauley RC, Sheehan PR, Staten MA, Phillips LS, Rasouli N and Pittas AG, D2d Research Group. Management of hemoglobin variants detected incidentally in HbA1c testing: a common problem currently lacking a standard approach. Diabetes Care 2017 Feb 40 (2):e8-e9.

Shahraz S, Pittas AG and Kent D. Less is More: Prediabetes risk in adult Americans According to a risk test. JAMA Internal Medicine 2016.

Pittas AG, Westcott G and Balk EM. Technosphere Inhaled Insulin for Patients with Diabetes: A Systematic Review and Meta-analysis Lancet Diabetes Endocrinol 2015:3(11):886-94.

Balk EM, Early A, Raman G, Avendano EA, Pittas AG and Remington PL. Combined Diet and Physical Activity Promotion Programs to Prevent Type 2 Diabetes Among Persons at Increased Risk: A Systematic Review for the Community Preventive Services Task Force. Ann Intern Med online 14 July 2015

Pittas AG, Dawson-Hughes B, Sheehan PR, Rosen CJ, Ware JH, Knowler WC, Staten MA and the D2d Research Group. Rationale and Design of the Vitamin D and Type 2 Diabetes Study: A Diabetes Prevention Trial. Diabetes Care 2014 Dec;37(12):3227-34.

Pittas AG, Nelson J, Mitri J, Hillmann W, Garganta C, Nathan DM, Hu FB and Dawson-Hughes B. Plasma 25-hydroxyvitamin D and progression to diabetes in patients at risk for diabetes: an ancillary analysis in the Diabetes Prevention Program. Diabetes Care 2012:35(3):565-573

Pittas AG, Chung M, Trikalinos TA, Mitri J, Brendel M, Patel K, Lichtenstein AH, Lau J and Balk E. Vitamin D and Cardiometabolic Outcomes: A Systematic Review. Ann Intern Med 2010:152(5):307-314

Amori R, Lau J and Pittas AG. Efficacy and Safety of Incretin Therapy in Type 2 Diabetes. Systematic Review and Meta-analysis JAMA 2007:298(2):194-206

Ceglia L, Lau J and Pittas AG. Efficacy and safety of inhaled insulin therapy in adults with diabetes mellitus. A systematic review. Ann Intern Med 2006:145:665-675

Dr. Anastassios Pittas was born and raised in Greece and came to the U.S. many years ago to attend college. At MIT, not only did he earn a B.S. degree in Biology, but also met his future spouse, Helen. Both earned their medical degrees at Weill Medical College of Cornell University and completed Internal Medicine Residencies at the New-York Presbyterian Hospital-Weill Cornell in New York City before moving to Boston. After completing a Fellowship in Endocrinology, Diabetes and Metabolism at Tufts Medical Center, Dr. Pittas joined the staff in the Division of Endocrinology in 2000 where he has remained active in all three areas of academic medicine, clinical care, research and teaching as they relate to the prevention and treatment of diabetes.

From 2000 and 2002, Dr. Pittas was supported by a generous grant from the Friedman NY Foundation for Medical Research. Dr. Pittas has been continuously funded by the National Institutes of Health since 2002, first as the recipient of a NIH K23 Career Development Award. During this period, in keeping with the goal of the Award, he earned a M.S. degree in Clinical Research from the Sackler School of Biomedical Sciences at Tufts University. The degree provided him with formal training on clinical research and during that time, he became interested in the role of vitamin D in diabetes. Working with wonderful colleagues, Dr. Pittas has received funding via the R01, R21, U34 and U01 mechanisms of the National Institutes of Health and the American Diabetes Association. He is currently the principal investigator and Chair of the vitamin D and type 2 diabetes study, a large (N=2,423 participants) multi-center clinical trial to test whether vitamin D supplementation reduces risk of diabetes in people at high risk. As study Chair, Dr. Pittas assembled a team of principal investigators at 22 clinical centers around the country, a central laboratory and drug distribution center, and directed the study’s Coordinating Center and oversaw the study’s $45 million 8-year budget. Details about the D2d study can be found at d2dstudy.org. Dr. Pittas has served as a member or Chair of multiple NIH study sections and for international research foundations, including the Canadian Institutes of Health Research, UK Diabetes, Children’s Medical Research Foundation (Australia) and Health Research Council of New Zealand. He has co-authored over 100 publications including peer-reviewed journals, books, book chapters and evidence-based reports.

In 2017, Dr. Pittas received a Biomedical Research Exemplar Award, which honors - at a national level - individuals conducting high-quality, high-impact, federally funded research who maintain an impressive reputation for professionalism and integrity in their work and who also employ exemplar practices to lead and manage their teams. Colleagues state that he embraces a culture of accountability and responsibility, always striving to define what success looks like at the individual (personal and professional), team, and project level. His research group is described as a fun, engaging place to work where no idea is suppressed, and staff have the freedom to make suggestions and execute improvements.

Throughout his career, Dr. Pittas has remained clinically active and has been recognized as a Boston Top Doc by Boston Magazine every year since 2017.

Dr. Pittas is a Professor of Medicine at Tufts University School of Medicine and Adjunct Professor of Nutrition and Policy at Tufts University Friedman School of Nutrition, Science and Policy. Dr. Pittas serves as the Associate Director of the Endocrinology Fellowship Program and co-Director of the Diabetes Clinic. From 2000 to 2008, he served as the Director of the Endocrine Pathophysiology course at Tufts University School of Medicine.

You can learn more about Dr. Pittas by visiting his website at agpittas.com/.

Top Doctor 2021

2021 “Top Doctors” at Tufts MC and Tufts Children's Hospital

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Top Doctors Boston Magazine 2020

2020 “Top Doctors” at Tufts MC and Tufts Children's Hospital

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Anastassios Pittas, MD an endocrinologist at Tufts Medical Center in Boston.

Does vitamin D ward off diabetes?

Learn more about the national study
Group of hands holding a silver ribbon with a blood drop on it.

Vitamin D does not reduce likelihood of developing diabetes

Learn more about the study
Boston Magazine 'Top Doctor' Award 2016

Boston magazine honors 2016 “Top Doctors” at Tufts Medical Center and Tufts Children's Hospital.

2016 Boston magazine Top Doctors
Anastassios Pittas, MD an endocrinologist at Tufts Medical Center in Boston.

Physician receives $40 Million NIH grant for nationwide clinical trial on vitamin D and diabetes.

Diabetes research granted $40 million
Anastassios Pittas, MD an endocrinologist at Tufts Medical Center in Boston.

Resilience and Innovation during Diabetes Awareness Month

Resilience and Innovation during Diabetes Awareness Month - Read More
A doctor and her patient at Tufts Medical Center in Boston.

Our researchers are using a grant from the NIH to study the impact of vitamin D on diabetes.

Learn more about our research
Boston Magazine 'Top Doctor' Award 2017

Boston Magazine honors 2017 “Top Doctors” at Tufts Medical Center and Tufts Children's Hospital.

2017 Boston Magazine Top Doctors
Dr. Clarissa Yang on the cover of 2019 Boston Magazine Top Doctor issue.

2019 “Top Doctors” at Tufts MC and Tufts Children's Hospital

See our Top Doctors
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Below is an outline of research interests and accomplishments and opportunities for collaborations and mentorship. Colleagues and trainees are welcome to bring ideas, energy, enthusiasm and time to the development and execution of collaborative projects with meaningful impact in patient care. For details, please also visit https://agpittas.com/.

Understanding of the role of vitamin D in type 2 diabetes. Through a methodical approach that included cross-sectional and longitudinal observational studies, post-hoc analyses of completed trials and short-term mechanistic trials, my colleagues from different institutions and I worked in a highly collaborative approach to uncover a link between vitamin D and risk of type 2 diabetes. Databases and specimens (blood / urine) are available from observational studies and randomized trials for ancillary studies by colleagues and trainees. Details can be found at www.vitaminDfordiabetes.org and www.d2dstudy.org.

Precision-Nutrition for prevention and management of diabetes and cardiometabolic disease. Based on animal work by others, my colleagues and I demonstrated that the effect of the dietary glycemic load on weight change depends on baseline insulin secretion, a finding which was subsequently confirmed by others.

Comparative Effectiveness Research as it relates to the care of patients with diabetes. Working collaboratively and effectively with researchers from the Tufts Evidence Based Center (for over 10 years) and currently with the Brown Evidence Based Center, my colleagues and I have conducted and published more than 10 high-impact systematic reviews and meta-analyses on topics that are timely and clinically applicable.

The application of virtual medicine and digital connectivity in the care of patients with diabetes and other endocrine conditions. Our team has conducted research in the use of continuous glucose monitoring in patients with pre-diabetes and diabetes, focusing on understanding its role in clinical care. Databases are available for analyses.

Mentorship of trainees. Under many roles in the Tufts educational environment (Associate Director of the Endocrinology Fellowship Program, Instructor for the Study Design and Clinical Trials courses at Tufts University), Dr. Pittas has served as mentor for a number of trainees at many academic levels and in wide areas of clinical research, including observational studies, trials and comparative effectiveness research. His trainees and Dr. Pittas have co-authored more than 40 manuscripts in the area of diabetes and metabolism.

1. The role of vitamin D in health and disease - Primary Care Physicians, Endocrinology
2. Pharmacotherapy of type 2 diabetes - Primary Care Physicians