Molecular Oncology Research Institute (MORI)
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Athan Kuliopulos, MD, PhD
Director, Hemostasis and Thrombosis Laboratory; Investigator, Division of Hematology Oncology; Professor of Medicine, Biochemistry and Genetics, Tufts University School of Medicine
Department + Services
Clinical Focus Areas
Thrombin and protease-activated receptor signaling
Protease-activated receptors (PARs) are a unique class of G protein-coupled receptors that play critical roles in thrombosis, inflammation, and vascular biology. The PARs are cleaved by thrombin and other proteases at a specific peptide bond to expose a new N-terminus that binds to the body of the receptor in an unusual intramolecular mode.
A major interest of our research group is to study the molecular mechanism of protease activation of the PARs and the subsequent signaling in vascular cells and in cancer.
Tufts Medical Center
800 Washington St., #5609
Boston, MA 02111