Share on facebook Share on Twitter Share on Google Plus Share This
Back to Results

Daniel Richards, PhD, MSci


Overview

Research Interests Echocardiography, exercise physiology, preclinical in vivo research
Gender Male

Honors + Awards

2016 - ISHR World Congress Travel Grant Winner; Buenos Aires, Argentina
2015 - Best Research Poster Presentation Award at ISHR Conference; Bordeaux, France
2012 - Peter J. Roberts Prize; Bristol, UK

Publications + National Presentations

Schnelle M, Catibog N, Zhang M, Nabeebaccus AA, Anderson G, Richards DA, Sawyer G, Zhang X, Toischer K, Hasenfuss G, Monaghan MJ, Shah AM. Echocardiographic evaluation of diastolic function in mouse models of heart disease. J Mol Cell Cardiol. 2017 Oct 19;114:20-28. doi: 10.1016/j.yjmcc.2017.10.006. [Epub ahead of print] PubMed PMID: 29055654.

Burgoyne JR, Prysyazhna O, Richards DA, Eaton P. Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG Iα (Protein Kinase G Iα). Hypertension. 2017 Sep;70(3):577-586. doi: 10.1161/HYPERTENSIONAHA.117.09670. Epub 2017 Jul 17. PubMed PMID: 28716990; PubMed Central PMCID: PMC5548503.

Aubdool AA, Thakore P, Argunhan F, Smillie SJ, Schnelle M, Srivastava S, Alawi KM, Wilde E, Mitchell J, Farrell-Dillon K, Richards DA, Maltese G, Siow RC, Nandi M, Clark JE, Shah AM, Sams A, Brain SD. A Novel α-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure. Circulation. 2017 Jul 25;136(4):367-383. doi: 10.1161/CIRCULATIONAHA.117.028388. Epub 2017 Apr 26. PubMed PMID: 28446517; PubMed Central PMCID: PMC5519346.

Sag CM, Schnelle M, Zhang J, Murdoch CE, Kossmann S, Protti A, Santos CXC, Sawyer G, Zhang X, Mongue-Din H, Richards DA, Brewer AC, Prysyazhna O, Maier LS, Wenzel P, Eaton PJ, Shah AM. Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure. Circulation. 2017 May 30;135(22):2163-2177. doi: 10.1161/CIRCULATIONAHA.116.023877. Epub 2017 Mar 15. PubMed PMID: 28298457; PubMed Central PMCID: PMC5444427.

Richards DA, Bao W, Rambo MV, Burgert M, Jucker BM, Lenhard SC. Examining the relationship between exercise tolerance and isoproterenol-based cardiac reserve in murine models of heart failure. J Appl Physiol (1985). 2013 May;114(9):1202-10. doi: 10.1152/japplphysiol.00556.2012. Epub 2013 Feb 28. PubMed PMID: 23449942.

Biography

Daniel Richards is from London, UK. In 2012, he completed an undergraduate Master’s degree in Pharmacology at the University of Bristol. This included a 12-month placement in the heart failure drug discovery unit at GlaxoSmithKline in Philadelphia, USA. He then attended King’s College London, where he first gained a Master’s in Cardiovascular Science in 2013, followed by a PhD in the laboratory of Prof. Ajay Shah. His thesis discussed the role of NADPH-Oxidase 2 in the development of cardiac fibrosis. Daniel joined the Molecular Cardiology Research Institute at Tufts Medical Center in 2017, working as a postdoctoral research fellow in the laboratory of Dr. Robert Blanton.

Professional Memberships

International Society for Heart Research
British Society for Cardiovascular Research

Research Focus

The role of PKG and PKG-interacting proteins in blood pressure regulation and the development of heart failure. This project aims to understand the protective role played by PKG in heart failure, using conventional gene deletion and CRISPR/Cas9-mediated models, with a long-term goal of targeting and promoting its activation.