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Department + Services
Cardiology, Molecular Cardiology Research Institute
Research Focus Areas
Atherosclerosis, inflammation, sex differences in cardiovascular disease, mineralocorticoid receptor, RAAS
2016: Awarded AHA Predoctoral Fellowship
2017: Awarded NIH/NHLBI F30 Predoctoral Fellowship
2017: 3rd Place, Charlton Poster Competition (Tufts University)
1. Diaz-Otero JM, Fisher C, Downs K, Moss ME, Jaffe IZ, Jackson WF, Dorrance AM. Endothelial Mineralocorticoid Receptor Mediates Parenchymal Arteriole and Posterior Cerebral Artery Remodeling During Angiotensin II-Induced Hypertension. Hypertension. 2017 Dec;70(6):1113-1121.
2. Salvador AM, Moss ME, Aronovitz M, Mueller KB, Blanton RM, Jaffe IZ, Alcaide P. Endothelial mineralocorticoid receptor contributes to systolic dysfunction induced by pressure overload without modulating cardiac hypertrophy or inflammation. Physiol Rep. 2017 Jun;5(12).
3. Marzolla V, Armani A, Mammi C, Moss ME, Pagliarini V, Pontecorvo L, Antelmi A, Fabbri A, Rosano G, Jaffe IZ, Caprio M. Essential role of ICAM-1 in aldosterone-induced atherosclerosis. Int J Cardiol. 2017 Apr 1;232:233-242.
4. Burke SD, Zsengellér ZK, Khankin EV, Lo AS, Rajakumar A, DuPont JJ, McCurley A, Moss ME, Zhang D, Clark CD, Wang A, Seely EW, Kang PM, Stillman IE, Jaffe IZ, Karumanchi SA. Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia. J Clin Invest. 2016 Jul 1;126(7):2561-74.
5. Moss ME, Jaffe IZ. Mineralocorticoid Receptors in the Pathophysiology of Vascular Inflammation and Atherosclerosis. Front Endocrinol (Lausanne). 2015 Sep 28;6:153.
Liz graduated from the Chemistry program at Boston University in 2013
while at BU she worked with Dr. Geoffrey Cooper studying apoptotic mechanisms in cardiomyocytes. She began the MD/PhD combined studies program at Tufts University School of Medicine in the summer of 2013 and spent the following two years in didactic medical training. In June of 2015 she joined the laboratory of Dr. Iris Jaffe, where she has been studying the role of the mineralocorticoid receptor in vascular cell types in inflammation and atherosclerosis. In the course of this training, she applied for and was awarded predoctoral fellowships from the American Heart Association and the National Heart, Lung, and Blood Institute of the NIH. After completing her MD/PhD training, she plan to combine clinical practice with research as a physician-scientist at an academic institution.
I am interested in understanding the mechanisms driving vascular inflammation in atherosclerotic heart disease and the role of the mineralocorticoid receptor and RAAS signaling in this process. In particular, I am interested in the apparent sex differences in the occurrence and severity of heart disease and inflammation and how the mineralocorticoid receptor might be playing a role in these differences. To that end, my work has utilized novel mouse models of atherosclerosis in which the cell-specific contribution of the mineralocorticoid receptor may be assessed. Further, I am directly comparing the inflammatory responses of male and female mice to investigate sex differences in inflammation and atherosclerosis.