|Programs + Specialties
||Preterm birth, preeclampsia, critical care obstetrics
|Training + Education
University of Cape Town Faculty of Health Sciences, South Africa; Brigham and Women's Hospital; Massachusetts General Hospital; Yale-New Haven Hospital
||Maternal Fetal Medicine, Obstetrics and Gynecology
||View Accepted Insurances at Tufts MC + Floating Hospital
Tufts Medical Center
800 Washington St, #324
Boston, MA 02111
Phone #: 617-636-2382
Fax #: 617-636-8315
2017, "Top Doctor," Boston Magazine
2016, Appointed Interim Chief Scientific Officer, Tufts Medical Center
2016, "Top Doctor," Boston Magazine
2015, "Top Doctor," Boston Magazine
2014, "Top Doctor," Boston Magazine
2013, "Top Doctor," Boston Magazine
2013, Appointed Member, March of Dimes Transdisciplinary Centers (TDC) Advisory Committee
2013, Appointed Member, Pregnancy and Neonatology (PN) Study Section, Center for Scientific Review, NIH/NICHD
2012, Appointed to Editorial Board, British Journal of Obstetrics and Gynaecology
2012, Appointed Member, Board of Directors, Tufts Medical Center Indemnity Company (TMCIC)
2012, Appointed Member, Board of Directors, Frontiers in Reproduction™
2012, "Top Doctor," Boston Magazine
2012, "Top Doctor" and in top 1% in the nation in his specialty, U.S. News & World Report
2011, Recipient, March of Dimes Award for Best Research in Prematurity, SMFM
2011, Best Oral Presentation at SMFM
2008, Recipient, Award for Best Oral Presentation, Society for Maternal-Fetal Medicine
2007, Fellow, American Gynecological and Obstetrical Society (AGOS)
2006, Fellow, Timothy Dwight College, Yale University
2006, Recipient, Charles A. Hunter, Jr. Award, Am. Gyn. & Obstetrical Society
2006, Recipient, March of Dimes Award for Best Research in Prematurity, SMFM
2005, Named to Best Doctors in America® list
2003, Recipient, Award for Best Oral Presentation, SMFM
2002, Recipient, Award for Best Oral Presentation, ACOG Distinct I Annual Mtg.
2000-02, NICHD Scholar of Women’s Reproductive Heath Research (WRHR)
2000-2001, Recipient, Leonard Safon Teaching Award in Obstetrics, Brigham & Women’s Hospital
1997-1999, APGO/NICHD Scholar of the Reproductive Scientist Development Program
1993-1994, Recipient, OB/GYN Resident Teaching Awards, BWH/Harvard University
Pavlicev M, Norwitz ER. Human parturition: nothing more than a delayed menstruation. Reprod Sci 2018;25:166-173.
van der Zwan A, Bi K, Norwitz ER, Crespo ÂC, Claas FHJ, Strominger JL, Tilburgs T. Mixed signature of activation and dysfunction allows human decidual CD8+ T cells to provide both tolerance and immunity. Proc Natl Acad Sci USA 2018;115:385-390.
Wang Y, Abrahams VM, Luo G, Norwitz NG, Snegovskikh VV, Ng SW, Norwitz ER. Progesterone inhibits apoptosis in fetal membranes by altering expression of both pro- and anti-angiogenic proteins. Reprod Sci 2018;doi: 10.1177/1933719118759440.
Palmeiro-Silva YK, Orellana P, Venegas P, Monteiro L, Varas-Godoy M, Norwitz E, Rice G, Osorio E, Illanes SE. Effects of earthquake on perinatal outcomes: A Chilean register-based study. PLoS One 2018;13:e0191340.doi: 10.1371/journal.pone.0191340.
Tadesse S, Norwitz NG, Guller S, Arcuri F, Toti P, Norwitz ER, Kidane D. Dynamics of base excision repair at the maternal-fetal interface in pregnancies complicated by preeclampsia. Reprod Sci 2017;24:856-864.
Chen X, Li SL, Luo GY, Norwitz ER, Ouyang SY, Wen HX, Yuan Y, Tian XX, He JM. Ultrasono-graphic characteristics of cortical sulcus development in the human fetus between 18 and 41 weeks of gestation. Chin Med J 2017;130:920-928.
Taracanova A, Alevizos M, Karagkouni A, Weng Z, Norwitz E, Conti P, Leeman SE, Theoharides TC. SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors. Proc Natl Acad Sci USA 2017;114:e4002-4009.doi:10.1073/pnas.1524845114.
Snegovskikh D, Souza D, Walton Z, Dai F, Rachler R, Garay A, Snegovskikh VV, Braveman FR, Norwitz ER. Point-of-care viscoelastic testing improves the outcome of pregnancies complicated by severe postpartum hemorrhage. J Clin Anesth 2017;44:50-56.
Lee HJ, Park TC, Kim JH, Norwitz E, Lee B. The influence of oral dydrogesterone and vaginal progesterone on threatened abortion: a systematic review and meta-analysis. Biomed Res In 2017;3616875. doi: 10.1155/2017/3616875.
Lee SM, Park JS, Norwitz ER, Kim SM, Lee J, Park CW, Kim BJ, Jun JK.
Presenting Twins Are Exposed to Higher Levels of Inflammatory Mediators than
Nonpresenting Twins as Early as the Midtrimester of Pregnancy. PLoS One. 2015 Jun
15;10(6):e0125346. doi: 10.1371/journal.pone.0125346. eCollection 2015. PubMed
PMID: 26076029; PubMed Central PMCID: PMC4468219.
Norwitz ER, Bonney EA, Snegovskikh VV, Williams MA, Phillippe M, Park JS,
Abrahams VM. Molecular Regulation of Parturition: The Role of the Decidual Clock.
Cold Spring Harb Perspect Med. 2015 Apr 27. pii: a023143. doi:
10.1101/cshperspect.a023143. [Epub ahead of print] PubMed PMID: 25918180.
Norwitz ER. Clarifying when to recommend progesterone to prevent preterm
birth: clear as mud. BJOG. 2015 Jan;122(1):92. doi: 10.1111/1471-0528.13108. Epub
2014 Oct 7. PubMed PMID: 25289941.
Bakaysa SL, Potter JA, Hoang M, Han CS, Guller S, Norwitz ER, Abrahams VM.
Single- and double-stranded viral RNA generate distinct cytokine and antiviral
responses in human fetal membranes. Mol Hum Reprod. 2014 Jul;20(7):701-8. doi:
10.1093/molehr/gau028. Epub 2014 Apr 9. PubMed PMID: 24723465; PubMed Central
Tadesse S, Kidane D, Guller S, Luo T, Norwitz NG, Arcuri F, Toti P, Norwitz
ER. In vivo and in vitro evidence for placental DNA damage in preeclampsia. PLoS
One. 2014 Jan 22;9(1):e86791. doi: 10.1371/journal.pone.0086791. eCollection
2014. PubMed PMID: 24466242; PubMed Central PMCID: PMC3899334.
Tadesse S, Luo G, Park JS, Kim BJ, Snegovskikh VV, Zheng T, Hodgson EJ,
Arcuri F, Toti P, Parikh CR, Guller S, Norwitz ER. Intra-amniotic infection
upregulates neutrophil gelatinase-associated lipocalin (NGAL) expression at the
maternal-fetal interface at term: implications for infection-related preterm
birth. Reprod Sci. 2011 Aug;18(8):713-22. doi: 10.1177/1933719110396722. Epub
2011 Mar 18. PubMed PMID: 21421891; PubMed Central PMCID: PMC3343092.
Snegovskikh VV, Bhandari V, Wright JR, Tadesse S, Morgan T, Macneill C,
Foyouzi N, Park JS, Wang Y, Norwitz ER. Surfactant protein-A (SP-A) selectively
inhibits prostaglandin F2alpha (PGF2alpha) production in term decidua:
implications for the onset of labor. J Clin Endocrinol Metab. 2011
Apr;96(4):E624-32. doi: 10.1210/jc.2010-1496. Epub 2011 Jan 26. PubMed PMID:
21270323; PubMed Central PMCID: PMC3070253.
Mesiano S, Wang Y, Norwitz ER. Progesterone receptors in the human pregnancy
uterus: do they hold the key to birth timing? Reprod Sci. 2011 Jan;18(1):6-19.
doi: 10.1177/1933719110382922. Epub 2010 Oct 1. Review. PubMed PMID: 20889955.
Lee HJ, Snegovskikh VV, Park JS, Foyouzi N, Han KT, Hodgson EJ, Guller S,
Norwitz ER. Role of GnRH-GnRH receptor signaling at the maternal-fetal interface.
Fertil Steril. 2010 Dec;94(7):2680-7. doi: 10.1016/j.fertnstert.2010.03.016. Epub
2010 Apr 18. PubMed PMID: 20400076.
Luo G, Abrahams VM, Tadesse S, Funai EF, Hodgson EJ, Gao J, Norwitz ER.
Progesterone inhibits basal and TNF-alpha-induced apoptosis in fetal membranes: a
novel mechanism to explain progesterone-mediated prevention of preterm birth.
Reprod Sci. 2010 Jun;17(6):532-9. doi: 10.1177/1933719110363618. Epub 2010 Apr 1.
PubMed PMID: 20360593.
Errol Norwitz, MD, is internationally recognized for his work in maternal-fetal medicine, particularly in the causes and prevention of preeclampsia and pre-term labor. His research includes the use of progesterone to delay preterm labor in high-risk women, the genetics of adverse pregnancy outcomes, and the molecular regulation of labor and delivery, both term and preterm. He is the Chair of Obstetrics and Gynecology at Tufts Medical Center, and a professor at Tufts University School of Medicine. He is board certified in Maternal Fetal Medicine and Obstetrics and Gynecology.
President, Pratt Ob/Gyn, Boston, MA
Medical Board, Tufts Medical Center, Boston, MA
Research Council, Tufts Medical Center, Boston, MA
Editor-in-Chief, Reviews in Obstetrics & Gynecology
2007-2010, Member, Obstetric Practice Committee, Yale-New Haven Hospital
2007-2010, Member, Gynecology Practice Committee, Yale-New Haven Hospital
2003-2010, Member, Quality Assessment Comm., Dept. of Ob/Gyn. & Repr. Biology, Yale-New Haven Hospital
2003, Chair, Mortality & Morbidity Conf., Dept. of Ob/Gyn. & Repr. Sciences, Yale-New Haven Hospital
Innate Immune Responses of Trophoblasts in Pregnancy.
The major goals of this project are to determine the regulation of TLR-2 and TLR-8 mediated inflammation and apoptosis in the normal first trimester trophoblast in response to bacterial and viral components.
Program: Function of Toll-Like Receptors Throughout Gestation.
Project: Role of Toll-Like Receptors and Glucocorticoid in Placental-Fetal Inflammation.
The major goals of this project are to understand the function of Toll-like receptors at the maternal-fetal interface throughout gestation, and their role in infection-associated pregnancy complications. These studies will focus on the inflammatory
function of TLRs 3 and 4 in the first trimester placenta (Project I) and the inflammatory function of TLRs 2, 3 and 4 in the decidua (Project II) and term placenta (Project III).
Burroughs Wellcome Fund
The Role of Placental Nod-Like Receptors in Infection-Associated Preterm Labor.
The major goals of this project are to determine the function of NLRs in the placenta and their role in infection-associated preterm labor.
March of Dimes
Progesterone Receptor Dysregulation and Preterm Birth.
To understand in detail the molecular mechanisms by which progesterone supplementation can prevent preterm birth in some high-risk parturients and, in particular, to characterize the role of the progesterone receptor in spontaneous preterm labor.
Role: Principal Investigator.
Vision Grant Award (Panda)
Role of TLR in Preeclampsia.
The major goal of this project was to delineate the role of TLR in the pathogenesis of preeclampsia.
A Proteomics Computational Approach to Preterm Delivery.
Uses proteomics and computational tools to classify pathogenetic entities within the preterm labor syndrome and identifies biomarkers with diagnostic and prognostic value.