Pruthi D, Khankin E, Blanton R, Aronovitz M, Burke S, Stillman I, McCurley A, Karumanchi SA, and Jaffe IZ. Exposure to Experimental Preeclampsia in Mice Enhances the Vascular Response to Injury Later in Life. Hypertension, 2015 (In Press).
Barrett Mueller K, Lu Q, Mohammad NN, Luu V, McCurley A, Williams GH, Adler GK, Karas RH, Jaffe IZ. Estrogen Receptor Inhibits Mineralocorticoid Receptor Transcriptional Regulatory Function. Endocrinology. 2014 Jul 22:en20141270.
Chen CW, Jaffe IZ, Karumanchi SA. Pre-eclampsia and cardiovascular disease. Cardiovasc Res. 2014 Mar 15;101(4):579-86. Pubmed Abstract
Dupont JJ, Hill MA, Bender SB, Jaisser F, Jaffe IZ. Aldosterone and Vascular Mineralocorticoid Receptors: Regulators of Ion Channels Beyond the Kidney. Hypertension. 2013 Dec 30. [Epub ahead of print] No abstract available. [PubMed - as supplied by publisher].
Pruthi D, McCurley A, Aronovitz M, Galayda C, Karumanchi SA, Jaffe IZ. Aldosterone Promotes Vascular Remodeling by Direct Effects on Smooth Muscle Cell Mineralocorticoid Receptors. Arterioscler Thromb Vasc Biol. 2013 Dec 5. [Epub ahead of print].
McGraw AP, Bagley J, Chen WS, Galayda C, Nickerson H, Armani A, Caprio M, Carmeliet P, Jaffe IZ.Aldosterone increases early atherosclerosis and promotes plaque inflammation through a placental growth factor-dependent mechanism. J Am Heart Assoc. 2013 Feb 22;2(1):e000018. doi: 10.1161/JAHA.112.000018.
Preston IR, Sagliani KD, Warburton RR, Hill NS, Fanburg BL, Jaffe IZ. Mineralocorticoid receptor antagonism attenuates experimental pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2013 May 15;304(10):L678-88. doi: 10.1152/ajplung.00300.2012. Epub 2013 Mar 1.
Ehsan A, McGraw AP, Aronovitz MJ, Galayda C, Conte MS, Karas RH, Jaffe IZ. Mineralocorticoid receptor antagonism inhibits vein graft remodeling in mice. J Thorac Cardiovasc Surg. 2013 Jun;145(6):1642-9, 1649.e1. doi: 10.1016/j.jtcvs.2012.08.007. Epub 2012 Sep 13.
McCurley A, Pires PW, Bender SB, Aronovitz M, Zhao MJ, Metzger D, Chambon P, Hill MA, Dorrance AM, Mendelsohn ME, Jaffe IZ. Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med. 2012 Sep;18(9):1429-33.
McCurley A, Jaffe IZ. Mineralocorticoid receptors in vascular function and disease. Mol Cell Endocrinol. 2012 Mar 24;350(2):256-65. doi: 10.1016/j.mce.2011.06.014. Epub 2011 Jun 24. Review.
Newfell BG, Iyer LK, Mohammad NN, McGraw AP, Ehsan A, Rosano G, Huang PL, Mendelsohn ME, Jaffe IZ.Aldosterone regulates vascular gene transcription via oxidative stress-dependent and -independent pathways. Arterioscler Thromb Vasc Biol. 2011 Aug;31(8):1871-80. doi: 10.1161/ATVBAHA.111.229070. Epub 2011 May 26
Jaffe IZ, Newfell BG, Aronovitz M, Mohammad NN, McGraw AP, Perreault RE, Carmeliet P, Ehsan A, and Mendelsohn ME. Placental Growth Factor Mediates Aldosterone-Dependent Vascular Injury. Journal of Clinical Investigation 2010; 120(11):3891-3900.
Caprio M, Newfell BG, la Sala A, Baur W, Fabbri A, Rosano G, Mendelsohn ME, Jaffe IZ. Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion. Circulation Research 2008;102(11):1359-1367.
Jaffe IZ, Mendelsohn ME. Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells. Circulation Research 2005;96(6):643-650.
Iris Zamir Jaffe is an Associate Professor of Medicine at Tufts University School of Medicine, Director of the MCRI, Co-Director of the MCRC, and a staff physician in the Division of Cardiology at Tufts Medical Center. She received her M.D. degree and a Ph.D. in Molecular Biology from the University of Pennsylvania in Philadelphia and completed her Internal Medicine training at the Massachusetts General Hospital followed by Cardiology fellowship training at the Brigham and Women's Hospital, both in Boston.
The primary focus of the Jaffe lab is to understand the molecular mechanisms underlying common vascular disorders including hypertension, vascular remodeling, and atherosclerosis with specific emphasis on the role of the renin-angiotensin-aldosterone system. The Jaffe laboratory demonstrated the presence of functional mineralocorticoid receptors (MR) in human vascular cells and is studying the role of vascular MR in cardiovascular function and disease. The lab uses in vitro molecular techniques in vascular cells, genome wide “omics” analyses of cardiovascular tissues, whole vessels studies of vascular function, and in vivo tissue-specific transgenic mouse models to study vascular structure, function, and responses to injury and atherogenic stimuli to identify the molecular mechanisms of vascular disease and identify novel treatment targets.