Molecular Cardiology Research Institute (MCRI)
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Iris Z. Jaffe, MD, PhD
Meet Iris Z. Jaffe, MD, PhD
Title(s)
Executive Director, Molecular Cardiology Research Institute (MCRI); Cardiologist; Director, Vascular Biology Research Center within the MCRI; Elisa Kent Mendelsohn Professor of Molecular Cardiology, TUSM
Department + Services
Molecular Cardiology Research Institute (MCRI), Medicine, CardioVascular Center, Cardiology
Clinical Focus Areas
General cardiology, resistant hypertension
Research Focus Areas
The primary focus of the Jaffe lab is to understand the molecular mechanisms underlying common vascular disorders including hypertension, vascular remodeling, and atherosclerosis with specific emphasis on the role of the renin-angiotensin-aldosterone system. The Jaffe laboratory demonstrated the presence of functional mineralocorticoid receptors (MR) in human vascular cells and is studying the role of vascular MR in cardiovascular function and disease. The lab uses in vitro molecular techniques in vascular cells, genome wide “omics” analyses of cardiovascular tissues, whole vessels studies of vascular function, and in vivo tissue-specific transgenic mouse models to study vascular structure, function, and responses to injury and atherogenic stimuli to identify the molecular mechanisms of vascular disease and identify novel treatment targets.
| Programs + Specialties |
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| Training + Education |
University of Pennsylvania School of Medicine; Massachusetts General Hospital; Brigham and Women's Hospital
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| Board Certifications |
Internal Medicine, Cardiovascular Disease |
| NPI # |
1073561163 |
| Gender |
Female |
| Accepted Insurances |
View Accepted Insurances at Tufts Medical Center
|
2018, Association of University Cardiologists (AUC) Elected Member
2017, Interurban Clinical Club, Elected Member
2017, Meredith S. and John A. Oates Lecturer, Vanderbilt University School of Medicine (First Woman to ever be invited to give this lectureship)
2016, Notable Teaching Recognition in the Medicine Clerkship, selected by Tufts University School of Medicine students.
2015, Milton O. and Natalie V. Zucker Prize for Research, Tufts University School of Medicine
2014, Established Investigator Award, American Heart Association
2014, American Heart Association Established Investigator Award
2014, Mid-Career Award for Research Excellence, AHA, High Blood Pressure Research Council
2013, Russo Family Charitable Foundation Pilot Project Research Award
2013, American Society of Hypertension Young Scholar Award
2013, American Society of Clinical Investigation (ASCI) Elected Member
Iris Jaffe, MD, PhD is the Elisa Kent Mendelsohn Professor of Molecular Cardiology and Executive Director of the Molecular Cardiology Research Institute (MCRI) at Tufts Medical Center, in Boston, MA where she is also an attending Cardiologist. Dr. Jaffe received her BA in Biochemistry, PhD in Molecular Biology, and MD degrees all at the University of Pennsylvania in Philadelphia. She completed her Internal Medicine Residency training at Massachusetts General Hospital, clinical Cardiology fellowship at Brigham and Women’s Hospital and Vascular Biology Research Fellowship in the MCRI at Tufts Medical Center, all in Boston, MA. Iris joined the faculty at Tufts Medical Center in 2005 and was promoted to Professor of Medicine at Tufts University School of Medicine in 2017.
Dr. Jaffe’s research combines her background in molecular and vascular biology with her interest as a clinical Cardiologist to explore molecular mechanisms that contribute to common cardiovascular diseases with a goal of identifying novel treatments. Her lab has specifically focused on the role of the aldosterone-responsive mineralocorticoid receptor (MR) in blood vessels and demonstrated a direct contribution to hypertension, atherosclerosis, vascular remodeling, vein graft failure, and pulmonary hypertension.
Dr. Jaffe is the recipient of numerous grants, awards and honors for her research discoveries, including the Established Investigator Award from the American Heart Association and she is an elected member of the American Society of Clinical Investigation (ASCI). Iris Jaffe has served as Associate Editor for Clinical Science and on the Editorial Boards of Endocrinology and Hypertension. She is a standing member of the NIH Vascular Cell and Molecular Biology (VCMB) Study Section which she currently chairs.
2019, Association of University Cardiologists, Elected Member
2018, Interurban Clinical Club, Elected Member
2011-2017, International Aldosterone Conference Executive Committee
2014, American Physiologic Society, Member
2013, American Society of Clinical Investigation, Elected Member
2012, Endocrine Society, Member
2012, American Heart Association-Hypertension Council, Member
2012, North American Vascular Biology Organization (NAVBO), Member
2010, American Heart Association-Atherosclerosis Thrombosis and Vascular Biology Council Member
2005, American Heart Association, Member
The primary focus of the Jaffe lab is to understand the molecular mechanisms underlying common vascular disorders including hypertension, vascular remodeling, and atherosclerosis with specific emphasis on the role of the renin-angiotensin-aldosterone system. The Jaffe laboratory demonstrated the presence of functional mineralocorticoid receptors (MR) in human vascular cells and is studying the role of vascular MR in cardiovascular function and disease. The lab uses in vitro molecular techniques in vascular cells, genome wide “omics” analyses of cardiovascular tissues, whole vessels studies of vascular function, and in vivo tissue-specific transgenic mouse models to study vascular structure, function, and responses to injury and atherogenic stimuli to identify the molecular mechanisms of vascular disease and identify novel treatment targets.
Iris Jaffe
Phone: 617-636-0620
Fax: 617-636-8991
Assistant, Xhulia Kanani
Phone: 617-636-9370
Email: xkanani@tuftsmedicalcenter.org
Molecular Cardiology Research Institute
Tufts Medical Center
800 Washington Street, 80
Boston, MA 02111
