Molecular Cardiology Research Institute (MCRI)

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Isabelle Draper, PhD

Programs + Specialties
Training + Education University of Science and Technology, Montpellier, France; University of California, San Francisco
Gender Female
Accepted Insurances View Accepted Insurances at Tufts Medical Center

1.Saha M, Rizzo SA, Ramanathan M, Hightower RM, Santostefano KE, Terada N, Finkel RS, Berg JS, Chahin N, Pacak CA, Wagner RE, Alexander MS, Draper I, Kang PB. Selective serotonin reuptake inhibitors ameliorate MEGF10 myopathy. Hum Mol Genet. 2019 Jul 15;28(14):2365-2377. doi: 10.1093/hmg/ddz064. PubMed PMID: 31267131; PubMed Central PMCID: PMC6606856..

2. Draper I, Saha M, Stonebreaker H, Salomon RN, Matin B, Kang PB. The impact of Megf10/Drpr gain-of-function on muscle development in Drosophila. FEBS Lett. 2019 Apr;593(7):680-696. doi: 10.1002/1873-3468.13348. Epub 2019 Mar 12. PubMed PMID: 30802937; PubMed Central PMCID: PMC6504253.

3. Bruels CC, Li C, Mendoza T, Khan J, Reddy HM, Estrella EA, Ghosh PS, Darras BT, Lidov HGW, Pacak CA, Kunkel LM, Modave F, Draper I, Kang PB. Identification of a pathogenic mutation in ATP2A1 via in silico analysis of exome data for cryptic aberrant splice sites. Mol Genet Genomic Med. 2019 Mar;7(3):e552. doi: 10.1002/mgg3.552. Epub 2019 Jan 28. PubMed PMID: 30688039; PubMed Central PMCID: PMC6418371.

4. Saha M, Reddy HM, Salih MA, Estrella E, Jones MD, Mitsuhashi S, Cho KA, Suzuki-Hatano S, Rizzo SA, Hamad MH, Mukhtar MM, Hamed AA, Elseed MA, Lek M, Valkanas E, MacArthur DG, Kunkel LM, Pacak CA, Draper I, Kang PB. Impact of PYROXD1 deficiency on cellular respiration and correlations with genetic analyses of limb-girdle muscular dystrophy in Saudi Arabia and Sudan. Physiol Genomics. 2018 Nov 1;50(11):929-939. doi: 10.1152/physiolgenomics.00036.2018. Epub 2018 Aug 31. PubMed PMID: 30345904; PubMed Central PMCID: PMC6293114.

5. Bennett AH, O'Donohue MF, Gundry SR, Chan AT, Widrick J, Draper I, Chakraborty A, Zhou Y, Zon LI, Gleizes PE, Beggs AH, Gupta VA. RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processes. PLoS Genet. 2018 Mar;14(3):e1007226. doi: 10.1371/journal.pgen.1007226. eCollection 2018 Mar. PubMed PMID: 29518074; PubMed Central PMCID: PMC5843160.

6. Saha M, Mitsuhashi S, Jones MD, Manko K, Reddy HM, Bruels CC, Cho KA, Pacak CA, Draper I, Kang PB. Consequences of MEGF10 deficiency on myoblast function and Notch1 interactions. Hum Mol Genet. 2017 Aug 1;26(15):2984-3000. doi: 10.1093/hmg/ddx189. PubMed PMID: 28498977; PubMed Central PMCID: PMC6075367.

7. Regna K, Kurshan PT, Harwood BN, Jenkins AM, Lai CQ, Muskavitch MA, Kopin AS, Draper I. A critical role for the Drosophila dopamine D1-like receptor Dop1R2 at the onset of metamorphosis. BMC Dev Biol. 2016 May 16;16(1):15. doi: 10.1186/s12861-016-0115-z. PubMed PMID: 27184815; PubMed Central PMCID: PMC4868058.

8. Harwood BN, Draper I, Kopin AS. Targeted inactivation of the rickets receptor in muscle compromises Drosophila viability. J Exp Biol. 2014 Nov 15;217(Pt 22):4091-8. doi: 10.1242/jeb.110098. Epub 2014 Oct 2. PubMed PMID: 25278473; PubMed Central PMCID: PMC4495466.

9. Draper I, Mahoney LJ, Mitsuhashi S, Pacak CA, Salomon RN, Kang PB. Silencing of drpr leads to muscle and brain degeneration in adult Drosophila. Am J Pathol. 2014 Oct;184(10):2653-61. doi: 10.1016/j.ajpath.2014.06.018. Epub 2014 Aug 8. PubMed PMID: 25111228; PubMed Central PMCID: PMC4188861.

10. Draper I. Model organisms offer new possibilities for discovery of therapeutics. Drug Discov Today Technol. 2013 Spring;10(1):e61-4. doi: 10.1016/j.ddtec.2013.02.004. PubMed PMID: 24050231.

11. Wooten EC, Hebl VB, Wolf MJ, Greytak SR, Orr NM, Draper I, Calvino JE, Kapur NK, Maron MS, Kullo IJ, Ommen SR, Bos JM, Ackerman MJ, Huggins GS. Formin homology 2 domain containing 3 variants associated with hypertrophic cardiomyopathy. Circ Cardiovasc Genet. 2013 Feb;6(1):10-8. doi: 10.1161/CIRCGENETICS.112.965277. Epub 2012 Dec 19. PubMed PMID: 23255317; PubMed Central PMCID: PMC3578062.

12. Draper I, Tabaka ME, Jackson FR, Salomon RN, Kopin AS. The evolutionarily conserved RNA binding protein SMOOTH is essential for maintaining normal muscle function. Fly (Austin). 2009 Oct-Dec;3(4):235-46. doi: 10.4161/fly.9517. Epub 2009 Oct 14. PubMed PMID: 19755840; PubMed Central PMCID: PMC2796714..

13. Draper I, Kurshan PT, McBride E, Jackson FR, Kopin AS. Locomotor activity is regulated by D2-like receptors in Drosophila: an anatomic and functional analysis. Dev Neurobiol. 2007 Feb 15;67(3):378-93. doi: 10.1002/dneu.20355. PubMed PMID: 17443795.

PCT patent applications. Tufts Medical Center, Inc., Children's Medical Center Corporation, assignee. Inventors Isabelle DRAPER (primary), Louis M. Kunkel, Matthew S. Alexander, Alan S. Kopin. Compositions and Methods for the Treatment of Muscular Disease, and Related Screening Methods. United States US 20140243378 A1. 2014”

Isabelle Reveillaud-Draper earned her PhD. in Biochemistry from the Université Montpellier 2/ Sciences et Techniques, Montpellier, France, studying the structural organization of small nuclear ribonucleoproteins. She then joined Dr. Tom Kornberg's laboratory at the University of California, San Francisco, for a post-doctoral position working on Drosophila development. As a research associate at the Linus Pauling Institute of Science and Medicine in Palo Alto, CA, she pioneered the expression of mammalian genes in transgenic Drosophila (i.e., mutant flies expressing the bovine superoxide dismutase) to facilitate investigations of the free radical theory of aging. She currently directs the MCRI Drosophila laboratory at Tufts Medical Center. Dr. Draper’s lab utilizes the fruit fly to expedite the characterization of genes relevant to human cardiac and skeletal muscle physiology and disease, with a specific emphasis on the role of RNA binding proteins (RBPs). The laboratory uses a broad array of complementary genetic, molecular, pharmacological and behavioral approaches applicable to the Drosophila model organism. MCRI fly models of muscular dystrophies and heart disease are generated and integrated in translational pipelines established at TMC and other research institutions. These pipelines include invertebrate and vertebrate model organisms, and human cell lines, to facilitate the discovery of novel drug targets and/or candidate therapeutics.

Phone: 617-636-1328

Molecular Pharmacology Research Center
Molecular Cardiology Research Institute
Tufts Medical Center
800 Washington Street, Box #7703
Boston, MA 02111