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John J. Xin, MD, PhD


Programs + Specialties
Training + Education West China University of Medical Sciences; University of Chicago
Board Certifications ABHI Certified
NPI # 1548762339
Gender Male
Language(s) Chinese
Accepted Insurances View Accepted Insurances at Tufts MC + Tufts Children's Hospital

Tufts Medical Center
800 Washington Street
Boston, MA 02111
Phone #: 617-636-7222
Fax #: 617-636-8302

2014-2016 New Investigator Award from Leukemia Research Foundation
2011-2014 Development Award from Muscular Dystrophy Association
2013 Travel Award, Chicago Association for Research and Education in Science
2012 “Young Investigator’s Educational Enhancement” travel award, American Society of Neurochemistry
2011 Semi-finalist, PepsiCo Research Competition
2011 3rd place, Hines VA Hospital Research competition
2007 Arthur J. Schmitt Dissertation Fellowship Award, Loyola University.
2007 Graduate Travel Award, Society for Neuroscience (SfN)
2007 First Place, Graduate Student Symposium, SfN Chicago Chapter
2006 3rd Place, St. Albert’s Day Research Presentation, Loyola University
1996 Outstanding Graduate of West China University of Medical Sciences (WCUMS)
1993-1996 Outstanding Student Fellowship of WCUMS

Development of anti-Bw4 antibody in the presence of Bw4+ HLA-B and HLA-A antigens. America Society for Histocompatibility and Immunogenetics (ASHI) 46th Annual Meeting, 20-A-61-ASHI

False pan-DR reactivities in a single antigen bead assay for a kidney transplant candidate. America Society for Histocompatibility and Immunogenetics (ASHI) 46th Annual Meeting, 20-CS-62-ASHI

Differential response of DSAs to the treatment in a heart transplant patient. America Society for Histocompatibility and Immunogenetics (ASHI) 46th Annual Meeting 20-CS-64-ASHI

Under-recognized DQA antibody in heart transplant patient International Society for Heart and Lung Transplantation, 40th Annual Meeting. 20-JF-4148-ISHLT

Revisiting BW6 reactivity pattern at different levels of MFI. Human Immunology 80 (2019), 188-189. DOI: 10.1016/j.humimm.2019.07.218

Multiple allele-specific antibodies against shared antigens in a kidney transplant patient. Human Immunology 80 (2019), 74. DOI: 10.1016/j.humimm.2019.07.078

DQA DSA and allograft failure in a heart transplant patient. Human Immunology 80 (2019), 74. DOI: 10.1016/j.humimm.2019.07.079

Persistent detection of anti-hla b8 by IgM and c1q testing in the post-transplant setting. Human Immunology 79 (2018), 95. https://doi.org/10.1016/j.humimm.2018.07.106 (*equal contribution)

An accelerated method for reverse sequence-specific oligonucleotide probe-based HLA typing. Human Immunology 79 (2018), 140. https://doi.org/10.1016/ j.humimm.2018. 07.164 (*equal contribution)

Pre-transplant Anti-nuclear Antibodies Correlate with Post-transplant Donor-specific Antibodies: A Link between Autoimmunity and Graft Failure? The Journal of Heart and Lung Transplantation, 37 (2018) S302-S303. https://doi.org/10.1016/j.healun.2018.01.768

EDTA fully overcomes the prozone effect in Luminex-based HLA antibody assays regardless of technical modifications. Human Immunology 78 (2017) 51–254; DOI: 10.1016/j.humimm.2017.06.272

A successful case of stem cell transplant after desensitization of a strong donor specific antibody. Human Immunology 78 (2017) 51–254; DOI: 10.1016/j.humimm.2017.06.089.

An algorithm for overcoming autoantibody interference in solid phase HLA antibody testing. Human Immunology 78 (2017) 51–254; DOI: 10.1016/j.humimm.2017.06.296

Impact of serum EDTA treatment on identification of unacceptable antigens for kidney transplant candidates. C24 Am J Transplant. 2017; 17 (suppl 3).

Antibody mediated rejection and donor specific antibodies in heart transplant patients: single center experience. ATC Annual Meeting (*equal contribution) C106 Am J Transplant. 2017; 17 (suppl 3).

False-positive flow cytometric crossmatch results and the utility of the virtual crossmatch. C22 Am J Transplant. 2017; 17 (suppl. 3).

J Liu, O Zheng, JG Xin, HH Chen, Xin JJ* How are necroptosis, immune dysfunction, and motoneuron death connected in ALS? Neuroimmunology and Neuroinflammation 2017, 4:109-16. DOI:10.20517/2347-8659.2017.12 (*Corresponding author).

Ni A, Yang T, Mesnard-Hoaglin N, Gutierrez R; Stubbs E, McGuire SO, Sanders VM, Jones KJ; Foecking EM; Xin J*. Th17 cell response in SOD1G93A mice following motor nerve injury. Mediator of Inflammation 2016, dx.doi.org/10.1155/2016/6131234. PMID: 27194826

Xin J*, You D, Breslin P, Li J, Zhang J, Wei W, Cannova J, Volk A, Gutierrez R, Xiao Y, Ni A, Ng G, Schmidt R, Xia Z, Pan J, Chen H, Patel MM, Kuo PC, Nand S, Kini AR, Zhang J, Chen J, Zhu J, Zhang J. Sensitizing acute myeloid leukemia cells to induced differentiation by inhibiting the RIP1/RIP3 pathway. Leukemia. 2016 Nov 18. doi: 10.1038/leu.2016.287. PMID: 27748372

Xin J*, Breslin P, Wei W, Li J, Gutierrez R, Cannova J, Ni A, Ng G, Schmidt R, Chen H, Parini V, Kuo PC, Kini AR, Stiff P, Zhu J, Zhang J. Necroptosis in spontaneously-mutated hematopoietic cells induces autoimmune bone marrow failure in mice. Haematologica. 2016. DOI: 10.3324/haematol.2016.151514. PMID: 27634200

You D, Xin J, Volk A, Wei W, Schmidt R, Scurti G, Nand S, Breuer EK, Kuo PC, Breslin P, Kini AR, Nishimura MI, Zeleznik-Le NJ, Zhang J. FAK Mediates a Compensatory Survival Signal Parallel to PI3K-AKT in PTEN-Null T-ALL Cells. Cell Report, 2015,10(12): 2055-2068. doi: 10.1016/j.celrep.2015.02.056. PMID: 25801032

Volk A, Li J, Xin J, You D, Zhang J, Liu X, Xiao Y, Breslin P, Li Z, Wei W, Schmidt R, Li X, Zhang Z, Kuo P, Nand S, Zhang J, Chen J, Zhang J. Sensitizing TNF-Expressing Acute Myeloid Leukemia Cells to NF-κB Inhibitor Treatment by Blocking TNF-JNK-AP1 Signaling. J Exp Med, 2014, 211(6):1093-108.doi: 10.1084/jem.20130990. PMID: 24842373

Xin J, Feinstein DL, Hejna MJ, McGuire SO. Beneficial effect of blueberries in Experimental Autoimmune Encephalomyelitis. Journal of Agricultural and Food Chemistry. 2012, 60(23):5743-8, DOI: 10.1021/jf203611t. PMID: 22243431

Xin J*, Mesnard NA, Bears T, Serpe CJ, Wainwright DA, Alexander TD, Sanders VM and Jones KJ. CD4+ T cell-mediated neuroprotection is independent of T cell-derived BDNF in a mouse facial nerve axotomy model. Brain, Behavior and Immunity. 2012, 26(6):886-90. PMID: 22426430

Xin J*, Fargo K, Tanzer L, Sanders VM and Jones KJ. T cell-mediated neuroprotection is dependent of estrogen action through estrogen receptor-alpha. Metabolic Brain Disease. 2012, 27(1): 23-8. PMID: 21975535.

Xin J*, Wainwright DA, Mesnard NA, Serpe CJ, Sanders VM and Jones KJ. The presence of IL-10 within the CNS is necessary for CD4+ T cells to mediate neuroprotection in a mouse facial nerve axotomy model. Brain, Behavior and Immunity, 2011, 25(5):820-9. PMID: 20723599

National presentations:

EDTA fully overcomes the prozone effect in Luminex-based HLA antibody assays regardless of technical modifications. Human Immunology 78 (2017) 51–254; DOI: 10.1016/j.humimm.2017.06.272; ASHI 43rd Annual Meeting

A successful case of stem cell transplant after desensitization of a strong donor specific antibody. Human Immunology 78 (2017) 51–254; DOI: 10.1016/j.humimm.2017.06.089. ASHI 43rd Annual Meeting

An algorithm for overcoming autoantibody interference in solid phase HLA antibody testing. Human Immunology 78 (2017) 51–254; DOI: 10.1016/j.humimm.2017.06.296; ASHI 43rd Annual Meeting

Impact of serum EDTA treatment on identification of unacceptable antigens for kidney transplant candidates. C24 Am J Transplant. 2017; 17 (suppl 3). ATC annual meeting

Dr. Xin's expertise is Transplant Immunology. He earned his medical degree at West China University of Medical Sciences, PhD at Loyola Medical Center. Fellowship training at University of Chicago. His professional interests include donor match for solid organ and stem cell transplant, as well as antibody monitoring pre- and post-transplant.

ASHI