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Lauren Biwer A, PhD


Overview

Research Interests Vascular cell signaling, endothelial dysfunction, microcirculation, cardiovascular pathophysiology, sex differences in cardiovascular function and disease
Training + Education University of Virginia; University of Virginia- PhD Molecular Physiology
Gender Female

Honors + Awards

University of Virginia Outstanding Graduate Student of the Year in Physiology (2017)
STIBET scholarship and support program from the German Academic Exchange Service (2017)
Benjamin W. Zwiefach Graduate Student Travel Award, Microcirculatory Society (2014, 2017)
American Heart Association Pre-Doctoral Fellowship (2014-2016)

Publications + National Presentations

1. Biwer LA, Good ME, Hong K, Patel RK, Agrawal N, Looft-Wilson R, Sonkusare SK, Isakson BE. Non endoplasmic reticulum calreticulin can coordinate heterocellular calcium signaling and vascular function. (In Press, ATVB)

2. Biwer LA, Lechauve C, Vanhoose S, Weiss MJ, Isakson BE. A Cell Culture Model of Resistance Arteries. J. Vis. Exp. (127), e55992, doi:10.3791/55992 (2017). PubMed PMID: 28930992

3. Biwer LA, Taddeo EP, Kenwood BM, Hoehn KL, Straub AC, Isakson BE. Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition. Biochim Biophys Acta 2016 April 19. PubMed PMID: 27106139

4. Biwer LA, Isakson BE. Endoplasmic reticulum mediated signaling in cellular microdomains. Acta Physiol (Oxf). 2016 Mar 12; 2017 Jan;219(1):162-175. doi: 10.1111/apha.12675. Epub 2016 Apr 5. PubMed PMID: 26973141.

5. Biwer LA, D'souza KM, Abidali A, Tu D, Siniard AL, DeBoth M, Huentelman M, Hale TM. Time course of cardiac inflammation during nitric oxide synthase inhibition in SHR: impact of prior transient ACE inhibition. Hypertens Res. 2016 Jan; 39(1):8-18. PubMed PMID: 26490086.

6. Biwer LA, Broderick TL, Xu H, Carroll C, Hale TM. Protection against L-NAME-induced reduction in cardiac output persists even after cessation of angiotensin-converting enzyme inhibitor treatment. Acta Physiol (Oxf). 2013 Jan; 207(1):156-65. PubMed PMID: 22834875.

7. D'Souza KM, Biwer LA, Madhavpeddi L, Ramaiah P, Shahid W, Hale TM. Persistent change in cardiac fibroblast physiology after transient ACE inhibition. Am J Physiol Heart Circ Physiol. 2015 Oct;309(8):H1346-53. PubMed PMID: 26371174.

8. Shu X, Keller TCS, Begandt D, Butcher JT, Biwer L, Keller AS, Columbus L, Isakson BE. (2015) Endothelial nitric oxide synthase in the microcirculation. Cellular and Molecular Life Sciences. PMID: 26390975

9. Billaud M, Lohman AW, Johnstone SR, Biwer LA, Mutchler S, Isakson BE. Regulation of cellular communication by signaling microdomains in the blood vessel wall. Pharmacol Rev. 2014;66(2):513-69. PMID: 24671377

10. Krüger NA, Biwer LA, Good ME, DeLalio LJ, Murphy S, Serbulea V, Leitinger N, Sonkusare SK, Gödecke A, Rüther U, Isakson BE. Loss of endothelial FTO antagonizes obesity induced metabolic and vascular alterations. (In review)

Biography

Dr. Lauren Biwer received her B.S.Ed. in Health Science Studies from Baylor University in 2009. She then worked as a research technician in Taben Hale's lab at the University of Arizona College of Medicine in Phoenix (UA COM PHX) for 3 years. While at UA COM PHX, she recieved a grant from the University of Arizona Sarver Heart Center to explore causes of arrhythmia in hypertensive heart failure. Lauren did her graduate research in the lab of Brant Isakson at University of Virginia School of Medicine (UVA), where she studied signaling processes in the myoendothelial junction of resistance arteries. At UVA, Lauren recieved an American Heart Association pre-doctoral fellowship and was the 2017 outstanding graduate student of the year in Physiology. Her publications demonstrate her unique skill set that includes experience in primary cell culture, molecular biology and microscopy, in addition to both ex-vivo and in vivo physiological techniques such as pressure myography, wire myography and measurement of blood pressure. Lauren joined the MCRI in 2017 as a postdoctoral fellow in Iris Jaffe's lab. Her research mechanistically explores the pathophysiology of cardiovascular disease, particularly as it relates to females with pre-existing cardiovascular risk factors such as hypertension, dyslipidemia, coronary artery disease and pre-eclampsia.

Professional Memberships

American Physiological Society
American Heart Association