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Mary C Wallingford, PhD


Programs + Specialties
Training + Education University of Massachusetts- Amherst, Department of Veterinary and Animal Science (PhD); Boston University SED; University of Washington Department of Bioengineering (Giachelli Lab); University of Washington School of Medicine Cardiovascular Training Grant Program (T32HL007828).
Gender Female

Honors + Awards

2018, Judge Travel Award for Annual Biomedical Research Conference for Minority Students (ABRCMS)
2017, NIH NICHD Pathway to Independence Award K99HD090198 (PI: Wallingford, MC)
2017, Perinatal Research Society Grant Writing Workshop NIH Young Investigator
2017, March of Dimes Conference Support Grant, joint with Manjiri Dighe and Martin Frasch
2017, UW SOM Office of Research and Graduate Education Conference Support Award
2016, University of Washington Office of Postdoctoral Affairs Travel Award
2016, Society for Developmental Biology Postdoc Travel Award
2013-2016, NIH NHLBI Cardiovascular Training Grant Program Trainee Appointment T32HL007828 (PI: Dichek, DM and Giachelli, CM)
2013, Society for Developmental Biology Science Illustration Flyer Competition Award Winner, Published in Dev Biol, 388(2): 148
2012, Veterinary and Animal Sciences Department Retreat First Place Poster
2012, Developmental Biology Student Image Competition First Place. Published in Dev Biol, 367(2): Cover Page
2011, Society for Developmental Biology Graduate Student Travel Award
2011, Society for Developmental Biology Annual Meeting Poster Competition Semi-finalist
2010, Northeastern Society for Developmental Biology Regional Meeting First Place Poster

Publications + National Presentations

For a complete list of Dr. Wallingford’s publications see:

Yamada Sa, Wallingford MCa, Borgeia S, Cox TC, and Giachelli CM. Loss of PiT-2 results in abnormal bone development and decreased bone mineral density and length in mice. Biochem Biophys Res Commun. 2017 Nov 11. pii: S0006-291X(17)32249-0. doi: 10.1016/j.bbrc.2017.11.071. [Epub ahead of print]

Wallingford MC, Benson C, Chavkin NW, Chin MT, Frasch MG. Placental vascular calcification and cardiovascular health: It is time to determine how much of maternal and offspring health is written in stone. Front. Physiol 2018;

Wallingford MC, Jacob H, Zhang K, and Mager J. YY1 is required for post-transcriptional stability of SOX2 and OCT4 proteins. Cellular Reprogramming. 2017;19(4):263-269. doi: 10.1089/cell.2017.0002.

Wallingford MC, Chia J, Leaf EM, Chavkin NW, Sawangmake C, Speer MY and Giachelli CM. Slc20a2 deficiency in mice leads to elevated phosphate levels in cerebrospinal fluid and glymphatic pathway-associated arteriolar calcification, and recapitulates human idiopathic basal ganglia calcification. Brain Pathology. 2017; 27(1): 64-76. doi: 10.1111/bpa.12362.

Lin M, Chen TM, Wallingford MC, Nguyen NB, Yamada S, Sawangmake C, Zhang J, Speer MY, and Giachelli CM. Runx2 deletion in smooth muscle cells inhibits vascular osteochondrogenesis and calcification but not atherosclerotic lesion formation. Cardiovascular Research. 2016; 112(2):606-616. doi: 10.1093/cvr/cvw205.

Wallingford MC, Gammill HS and Giachelli CM. Slc20a2 deficiency results in fetal growth restriction and placental calcification associated with thickened basement membranes and novel CD13 and laminin expressing cells. Reproductive Biology. 2016; 16(1):13-26. doi: 10.1016/j.repbio.2015.12.004. Shin JD, Wallingford MC, Gallant J, Marcho C, Jiao B, Byron M, Bossenz M, Lawrence JB, Jones SN, Mager J and Bach I. Rnf12 is dispensable for X chromosome inactivation in the mouse embryonic epiblast. Nature Genetics. 2014; 3;511(7507):86-9. doi: 10.1038/nature13286.

Wallingford MC and Giachelli CM. Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm. Mechanisms of Development. 2014; 133:189-202, doi: 10.1016/j.mod.2014.08.001.

Crouthamel MH, Lau WL, Leaf EM, Peterson DF, LiX, Liu Y, Chin MT, Levi M, Wallingford MC, Chavkin N and Giachelli CM. Sodium-dependent phosphate co-transporters and phosphate-induced calcification of vascular smooth muscle cells: Redundant roles for PiT-1 and PiT-2. Arteriosclerosis, Thrombosis and Vascular Biology. 2013; 33:2625-2632. doi: 10.1161/ATVBAHA.

Wallingford MC, Angelo JR and Mager J. Morphogenetic Analysis of Peri-implantation Development. Developmental Dynamics. 2013; 242(9):1110-20. doi: 10.1002/dvdy.23991.

Trask MC*, Tremblay KD and Mager J. Yin-Yang1 is required for epithelial-to-mesenchymal transition and regulation of Nodal signaling during mammalian gastrulation. Developmental Biology. 2012; 368:273-282. doi: 10.1016/j.ydbio.2012.05.031.


Mary Wallingford was trained in the field of embryonic development in the Mager Lab at the University of Massachusetts Amherst. Her doctoral research evaluated roles of the transcription factor and epigenetic regulator YY1 in early embryogenesis, including preimplantation, peri-implantation, and gastrulation stages. Her postdoctoral research in the Giachelli Lab at the University of Washington investigated the role of phosphate transporters in vascular development and disease at blood tissue barriers. She identified a novel cause of Slc20a2-linked neurovascular calcification and built an independent research program in phosphate transport biology of the maternal-fetal intferface. This work was supported in part by a trainee appointment in the NHLBI funded UW Cardiovascular Training Grant Program (PI: D. Dichek, T32HL007828) and by a K99/R00 Pathway to Independence Award from the NICHD (PI: M. Wallingford, K99HD090198). Dr. Wallingford’s current research brings the fields of embryology and vascular disease together to focus on development and pathophysiology of the least understood human organ: the placenta.

Professional Memberships

Perinatal Research Society (PRS), Associate Member
Society for Reproductive Investigation (SRI)
North American Vascular Biology Organization (NAVBO)
Society of Developmental Biology (SDB)
American Association for the Advancement of Sciences (AAAS)

News, Media + Videos

Research Grants

NIH/NICHD K99HD090198 2017-2021 Determination ff Maternal-Fetal Phosphate Transport Mechanisms and the Role ff Sodium-Dependent Phosphate Transporters in Extraembryonic Tissues. The major goals of this project are to determine molecular mechanisms of phosphate transport at the maternal-fetal interface, evaluate mechanisms of phosphate transport during pregnancy, and develop new technologies for assessment of placental development and physiology. Role: Principal Investigator

UW SOM Office of Research and Graduate Education Grant 2017-2018 University of Washington School of Medicine UW Placenta Research Network Seminars. The goal of this seminar series was to provide continued education and research support to placenta researchers in the Pacific Northwest. Role: Organizer, MPI

March of Dimes Scientific Conference Support Grant 2017 University of Washington School of Medicine The Placenta: Connecting People and Promoting Growth. The goals of this symposium were to provide education on placenta biology to trainees and those new to placenta research and to promote the development of collaborative, interdisciplinary placenta research projects. Role: Organizer, MPI with Manjiri Dighe (UW Radiology) and Martin Frasch (UW ObGyn)

NIH/NHLBI T32HL007828 Cardiovascular Training Grant Program 2013-2016 University of Washington School of Medicine The Role of Phosphate Transporters in Cardiovascular Development and Disease in the Mouse. The major goal of this project was to determine the role of phosphate transporters Slc20a1 and Slc20a2 in vascular calcification mechanisms at blood tissue barriers, including cerebral vessels (blood brain barrier) and extraembryonic tissues (blood placenta barrier). Role: Trainee, Mentored by David Dichek (UW Cardiology) and Cecilia Giachelli (UW Bioengineering)

Research Focus

The research focus in the Wallingford Lab is development and pathophysiology of the placenta. The placenta contains highly specialized vasculature that mediates interaction between maternal and fetal circulatory systems during pregnancy. Impaired placental growth or function can have dire impact on maternal and fetal health. In the long-term, Dr. Wallingford aims to advance knowledge of placental development and assist in the development of early diagnostics and novel therapeutics for disorders of placental insufficiency or dysfunction. Specific areas of interest include maternal-fetal phosphate transport biology, morphogenetic analysis of placentation, and development of new approaches to assess vascular structure and function at the maternal-fetal interface.