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Miaofen G. Hu, MD, PhD


Overview

Training + Education Wenzhou Medical College, China; Boston University School of Medicine; Harvard University School of Medicine
Gender Female

Publications + National Presentations

  1. Gu MF, Luo ZK (1990) Carbamazepine as an effective drug for the treatment of periodical mental disorder in siblings: case report. Chinese J. Neuro. Psych. Res. 168: 52-54.
  2. Schw JM, Boulis NM, Gu MF, Winickoff J, Jackson PS, Irwin N, Benowitz LI. Two factors secreted by the goldfish optic nerve induce retinal ganglion cells to regenerate axons in culture. J Neuroscience 1995; 15(8): 5514-5525.
  3. Schwalb JM, Gu MF (Co-First Author), Stuermer C, Bastmeyer M, Hu GF, Boulis N, Irwin N, Benowitz LI. Optic nerve glia secrete a low-molecular-weight factor that stimulates retinal ganglion cells to regenerate axons in goldfish. Neuroscience 1996; 72(4): 901-910.
  4. Takizawa T, Gu M, Chobanian AV, Brecher P. Effect of nitric oxide on DNA replication induced by angiotensin II in rat cardiac fibroblasts. Hypertension 1997; 30 (5): 1035-1040.
  5. Gu M, Brecher P. Nitric oxide-induced increase in p21Sdi1/Cip1/Waf1 expression during the cell cycles in aortic adventitial fibroblasts. Arterioscler Thromb Vasc Biol. 2000; 20(1): 27-34.
  6. Gu M, Lynch J and Brecher P. Nitric oxide increases p21Waf1/Cip1 expression by a cGMP-dependent pathway that includes activation of extracellular signal-regulated kinase and p70S6K.  J Biol Chem, 2000; 275: 11389-11396.
  7. Shintani S, Ohyama H, Zhang X, McBride J, Matsuo K, Tsuji K, Hu MG, Hu G-F, Kohno Y, Lerman M, Todd R, and Wong DTW. P12DOC-1 is a novel cyclin-dependent kinase 2-associated protein. Mol Cell Biol 2000; 20(17): 6300-6307.
  8. Hu MG, Hu G-F, Kim Y, Tsuji T, McBride J, Hinds PW and Wong DTW. P12DOC-1 mediates TGF-ß1 antiproliferation by negatively regulating CDK2 phosphorylation of pRB. Cancer Res. 2004; 64(2): 490-499
  9. Tsuji T, Ibaragi S, Shima K, Hu MG, Katsurano M, Sasaki A, and Hu G-F. Epithelial-Mesenchymal Transition Induced by Growth Suppressor p12CDK2-AP1 Promotes Tumor Cell Local Invasion but Suppresses Distant Colony Growth. Cancer Res. 2008; 68: (24): 10377-10386. PMCID: PMC2605670
  10. Hu MG*, Deshpande A, Enos M, Mao D, Hinds EA, Hu G-F, Chang R, Guo Z, Dose M, Mao C, Tsichlis PN, Gounari F, Hinds PW*. A Requirement for CDK6 in Thymocyte Development and Tumorigenesis. Cancer Res. 2009, 69: (3) 810-818 (*corresponding author). PMCID: PMC2636510
  11. Ibaragi S, Yoshioka N, Li S, Hu MG, Kishikawa S, and Hu G-F. Neamine Inhibits Prostate Cancer Growth by Suppressing Angiogenin-mediated Ribosomal RNA transcription. Clinical Cancer Res. 2009 Mar 10:1981-1988. PMCID: PMC2670466.
  12. Monti DM, Yu W, Pizzo E, Shima K, Hu MG, Di Malta C, Piccoli R, D'Alessio G, Hu GF. Characterization of the angiogenic activity of zebrafish ribonucleases. FEBS J. 2009 Aug; 276(15):4077-90. Epub 2009 Jun 22. PMCID: PMC2744113.
  13. Jeselsohn R, Brown NE, Klebba I, Hu MG, Kuperwasser C, Hinds PW. Lobule progenitor cells are the cellular targets of MMTV-ErbB2 tumorigenesis and require cyclin D1 activity for their maintenance. Cancer Cell. 2010 17 (1); 65-76. PMCID: PMC2818730
  14. Hu MG*, Deshpande A, Schlichting N, Hinds EA, Mao C, Dose M, Hu G-F, Van Etten RA, Gounari F, Hinds PW*. CDK6 Kinase Activity is required for Thymocyte Development (*corresponding author, Blood, 2011, 117: 6120-31).
  15. Brown NE, Jeselsohn R, Bihani T, Miaofen Hu MG, Foltopoulou P, Kuperwasser C, Hinds PW. Cyclin D1 activity regulates autophagy and senescence in the mammary epithelium (Cancer Res. 2012 Oct 29. [Epub ahead of print] PMID: 23041550 [PubMed - as supplied by publisher].
  16. Li S, Sheng JH, Hu JK, Yu WH, Kishikawa H, Hu MG, Shima K, Wu D, Xu ZP, Xin W, Sims KB, Landers JE, Brown Jr. RH, Hu GH. Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress. Angiogenesis. 2012. DOI 10.1007/s10456-012-9322-9.
  17. Luo C, Sheng J, Hu MG, Haluska FG, Cui R, Xu Z, Tsichlis PN, Hu GF, Hinds PW *. Loss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC. Cancer Research, Epub May 6, 2013, doi: 10.1158/0008-5472.CAN-12-4454. PMID: 23650282
  18. Li S, Hu MG, Sun Y, Yoshioka N, Ibaragi S, Sheng J, Sun G, Kishimoto K, Hu GF. Angiogenin mediates androgen-stimulated growth of prostate cancer cells and correlates with castration resistance (Mol Cancer Res. 2013 Oct;11(10):1203-14. doi: 10.1158/1541-7786.MCR-13-0072. Epub 2013 Jul 12. PMID: 23851444).
  19. Luo, C., Pietruska, J., Cui, R., Bronson, R., Hu MG, Sheng, J., Hunds, PW. Expression of oncogenic BRAFV600E in melanocytes induces Schwannian differentiation in vivo.  (Pigment Cell & Melanoma Research, 2015, Jun 2. doi: 10.1111/pcmr.12384, PMID: 26036358).
  20. Nilamani Jena, Jinghao Sheng, Jamie K Hu, Wenhui Zhu, Gene lee, Chi Luo, Elisabeth A Hinds, Nelson Brown, Amit Deshpande, Philip W Hinds, Phil Hinds, Richard A Van Etten, and Hu MG*. CDK6-mediated repression of CD25 is required for induction of T cell acute lymphoblastic leukemia by activated Notch (*corresponding author, Leukemia. 2015 Dec 28. doi: 10.1038/leu.2015.353. [Epub ahead of print], NIHMS745049).
  21. Goncalves, KA., Silberstein, L., Li, S., Severe, N., Hu, MG., Yang, HL., Scadden, DT., and Hu, GF. Angiogenin promotes hematopoietic regeneration by dichotomously regulating quiescence and expansion of stem and progenitor cells. Cell 166, 894–906, August 11, 2016. NIHMSID: NIHMS800636. PMID: 27518564 PMCID: PMC4988404.

Research Focus

We study the role of CDK6 in T-cell development and Leukemogenesis, with the particular focus on Notch-mediated stem cell transformation and Leukemogenesis.

Contact Information

Phone: 617-636-4929

Email: Miaofen Hu

Molecular Oncology Research Institute
Tufts Medical Center
800 Washington Street, Box #5609
Boston, MA 02111