Tufts Medical Center
South Building, 2nd Floor
800 Washington St.
Boston, MA 02111
Phone #: 617-636-4549
Fax #: 617-636-4202
2021, Appointed Member, Intramural - Extramural Collaboration for Drug Screening with Biofabricated 3-D Disease Tissue Models (UH2/UH3) NIH Study Section
2020, Appointed to the Board of the Perinatal Quality Foundation (ex-officio)
2016-2021, "Top Doctor," Boston Magazine
2013, Elected President of New England Perinatal Research Society
2012, Elected Vice-President of New England Perinatal Research Society
2012, Award for Best Poster at 32nd Annual Meeting, SMFM
2008, Elected member, Perinatal Research Society
2007, Reproductive Scientist Development Program, K12 Award, NICHD
2006, Best Oral Presentation at SMFM
2005, Best Oral Presentation at SMFM
2002, AAAOGF - SMFM Scholarship Award
Raia NR, Bakaysa SL, Ghezzi CE, House MD, Kaplan DL. Ex vivo pregnant-like tissue model to assess injectable hydrogel for preterm birth prevention. J Biomed Mater Res B Appl Biomater. 2020 Feb;108(2):468-474.
Koullali B, Zhang Y, Peterson A, Raia N, Kaplan DL, House MD. Cervical Augmentation with an Injectable Silk-Based Gel: Biocompatibility in a Rat Model of Pregnancy. Reprod Sci. 2020 May;27(5):1215-1221. doi: 10.1007/s43032-019-00111-7. Epub 2020 Jan 6. PubMed PMID:32046447; NIHMSID:NIHMS1548296.
Zhang Y, Raia N, Peterson A, Kaplan DL, House M. Injectable Silk-Based Hydrogel as an Alternative to Cervical Cerclage: A Rabbit Study. Tissue Eng Part A. 2020 Apr;26(7-8):379-386. doi: 10.1089/ten.TEA.2019.0210. Epub 2019 Nov 14. PubMed PMID:31621512; PubMed Central PMCID:PMC7187963.
Koullali B, House MD. Scaffolds for cervical tissue engineering. In: Mozafari M, Sefat F, Atala A editos. Handbook of Tissue Engineering Scaffolds: Volume Two, 1st ed. Elsevier; 2019. p 333-342.
Raia NR, Bakaysa SL, Ghezzi CE, House MD, Kaplan DL. Ex vivo pregnant-like tissue model to assess injectable hydrogel for preterm birth prevention. J Biomed Mater Res B Appl Biomater. 2020 Feb;108(2):468-474. doi: 10.1002/jbm.b.34403. Epub 2019 May 9. PubMed PMID:31070848.
House M, Kelly J, Klebanov N, Yoshida K, Myers K, Kaplan DL. Mechanical and Biochemical Effects of Progesterone on Engineered Cervical Tissue. Tissue Eng Part A. 2018 Dec;24(23-24):1765-1774. doi: 10.1089/ten.TEA.2018.0036. Epub 2018 Jul 23. PubMed PMID:29855229; PubMed Central PMCID:PMC6302671.
Westervelt AR, Fernandez M, House M, Vink J, Nhan-Chang CL, Wapner R, Myers KM. A parameterized ultrasound-based finite element analysis of the mechanical environment of pregnancy. J Biomech Eng 2017;139.doi:10.1115/1.4036259.
Smith-Dupont KB,Wagner CE, Witten J, Conroy K, Rudoltz, Pagidas, Snegovskikh V,7, House M, Ribbeck K. Probing the potential of mucus permeability to signify preterm birth risk. Sci Rep 2017;7:10302.doi: 10.1038/s41598-017-08057-z.
Myers KM, Feltovich H, Mazza E, Vink J, Bajka M, Wapner RJ, Hall TJ, House M.
The mechanical role of the cervix in pregnancy. J Biomech. 2015 Jun
25;48(9):1511-23. doi: 10.1016/j.jbiomech.2015.02.065. Epub 2015 Mar 11. PubMed
PMID: 25841293; PubMed Central PMCID: PMC4459908.
Feltovich H, House M. Innovative methods of cervical assessment and potential
for novel treatment. Clin Obstet Gynecol. 2014 Sep;57(3):531-6. doi:
10.1097/GRF.0000000000000049. Review. PubMed PMID: 25084285; PubMed Central
Critchfield AS, Mccabe R, Klebanov N, Richey L, Socrate S, Norwitz ER, Kaplan
DL, House M. Biocompatibility of a sonicated silk gel for cervical injection
during pregnancy: in vivo and in vitro study. Reprod Sci. 2014
Oct;21(10):1266-73. doi: 10.1177/1933719114522551. Epub 2014 Feb 11. PubMed PMID:
House M, Tadesse-Telila S, Norwitz ER, Socrate S, Kaplan DL. Inhibitory
effect of progesterone on cervical tissue formation in a three-dimensional
culture system with human cervical fibroblasts. Biol Reprod. 2014 Jan
30;90(1):18. doi: 10.1095/biolreprod.113.112540. Print 2014 Jan. PubMed PMID:
24285720; PubMed Central PMCID: PMC4076401.
Critchfield AS, Yao G, Jaishankar A, Friedlander RS, Lieleg O, Doyle PS,
McKinley G, House M, Ribbeck K. Cervical mucus properties stratify risk for
preterm birth. PLoS One. 2013 Aug 1;8(8):e69528. doi:
10.1371/journal.pone.0069528. Print 2013. PubMed PMID: 23936335; PubMed Central
Heard AJ, Socrate S, Burke KA, Norwitz ER, Kaplan DL, House MD. Silk-based
injectable biomaterial as an alternative to cervical cerclage: an in vitro study.
Reprod Sci. 2013 Aug;20(8):929-36. doi: 10.1177/1933719112468952. Epub 2012 Dec
27. PubMed PMID: 23271162; PubMed Central PMCID: PMC3713644.
7. House M, McCabe R, Socrate S. Using imaging-based, three-dimensional models
of the cervix and uterus for studies of cervical changes during pregnancy. Clin
Anat. 2013 Jan;26(1):97-104. doi: 10.1002/ca.22183. Epub 2012 Nov 21. Review.
PubMed PMID: 23168534.
House M, Daniel J, Elstad K, Socrate S, Kaplan DL. Oxygen tension and
formation of cervical-like tissue in two-dimensional and three-dimensional
culture. Tissue Eng Part A. 2012 Mar;18(5-6):499-507. doi:
10.1089/ten.TEA.2011.0309. Epub 2011 Nov 1. PubMed PMID: 21919792; PubMed Central
Myers KM, Socrate S, Paskaleva A, House M. A study of the anisotropy and
tension/compression behavior of human cervical tissue. J Biomech Eng. 2010
Feb;132(2):021003. doi: 10.1115/1.3197847. PubMed PMID: 20370240.
House M, Sanchez CC, Rice WL, Socrate S, Kaplan DL. Cervical tissue
engineering using silk scaffolds and human cervical cells. Tissue Eng Part A.
2010 Jun;16(6):2101-12. doi: 10.1089/ten.TEA.2009.0457. PubMed PMID: 20121593;
PubMed Central PMCID: PMC2949265.
Small Business Technology Transfer (STTR) Program
A Novel Device for Cervical Insufficiency in Pregnant Women
This STTR will develop an innovative medical device to treat cervical insufficiency with improved efficacy and fewer complications compared with traditional cerclage.
M2D2 Grand Prize Award
Massachusetts Life Sciences Center
Massachusetts Medical Device Development Center
The goal is to assist Cx Therapeutics in Developing an Innovative Medical Device to Treat Cervical Insufficiency Compared with Traditional Cerclage.
COVID-19 Rapid Response Seed Funding Grant
Reducing the stress associated with performing non-stress tests – evaluating potential acceptance for home-based monitoring.
The study aims to gather information that can inform how to approach home-based non-stress tests; the likelihood that a test would result in a patient needing clinical care acutely via a retrospective chart review and the perspective of patients who would potentially undergo home-based testing with a prospective survey.
SMFM/ABOG Bridge Grant
Novel tools for studying cervical function and dysfunction during pregnancy.
The goal of the project is to gain critical insights into mechanisms of preterm birth where cervical dysfunction is the cause.
Role: Principal Investigator
“Mechanisms of Infection-Mediated Cervical Ripening.”
The goal of this project is to acquire a greater mechanistic understanding of biochemical pathways leading to cervical ripening, with a particular emphasis on infection-mediated cervical ripening.
Role: Co-Principal Investigator
MIT: Burroughs Wellcome Fund
Sub Award #5710003419 2013-2017
Properties and Functions of Cervical Mucus Associated with Preterm Birth
The goal is to increase understanding of the basic biological mechanisms underlying parturition and spontaneous birth using multidisciplinary approaches.
Role: TMC Principal Investigator
A computational framework for the clinical evaluation of the soft tissue mechanics in pregnancy to understand what causes the mechanical dysfunction in pregnancy, a finite element (FE) simulation framework will be built to identify the anatomical and/or material factors that drive uterine, cervical, and fetal membrane tissue remodeling and deformation.
NICHD Scholar of the RSDP
Cervical Tissue Engineering for Studying Obstetrical Biomechanics.
The goal is to use a tissue engineering strategy to study mechanisms of cervical remodeling during pregnancy.
Role: Principal Investigator
Burroughs Wellcome Fund – Preterm Birth Initiative
Beyond Cervical Length: Development of a Patient-Specific Model of Cervical Mechanical Function during Pregnancy.
The goal of this study was to determine biomechanical function of the cervix during pregnancy by combining three-dimensional ultrasound with biomechanical models of cervical mechanics.
Role: Principal Investigator
Dr. House's research focus is on studying the role of the cervix in normal and high-risk pregnancy. Normal cervical function is critical for a healthy pregnancy but premature cervical shortening and dilation is associated with preterm birth, which affects 12% of pregnancies in the United States. Research activities include 1) design and evaluation of three-dimensional models of cervical tissue to study remodeling of the cervical extracellular matrix, 2) investigation of the cervical biomechanical function using mechanical modeling techniques, 3) study of the barrier properties of cervical mucus as it relates to protection against intrauterine infection and 4) development of novel therapies such as injectable biomaterials to augment cervical function during pregnancy. This research is valuable for understanding why the cervix stays closed in normal pregnancy but shortens and opens in preterm birth. Successful accomplishment of this research relies on a collaborative multidisciplinary research team involving investigators with expertise in mechanical engineering, biology and maternal fetal medicine.