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Michael D. House, MD accepting new patients


Programs + Specialties
Training + Education University of Southern California; Tufts Medical Center; Los Angeles County, University of Southern California Women and Children's Hospital
Board Certifications Maternal-Fetal Medicine, Obstetrics and Gynecology
NPI # 1851405740
Gender Male

Locations + Directions

Tufts Medical Center
South Building, 2nd Floor
800 Washington St.
Box 360
Boston, MA 02111
Fax #: 617-636-4202
Phone #: 617-636-4549

Honors + Awards

2013 Elected President of New England Perinatal Research Society

2012 Elected Vice-President of New England Perinatal Research Society

2012, Award for Best Poster at 32nd Annual Meeting, SMFM

2008, Elected member, Perinatal Research Society

2007, Reproductive Scientist Development Program, K12 Award, NICHD

2006, Best Oral Presentation at SMFM

2005, Best Oral Presentation at SMFM

2002, AAAOGF - SMFM Scholarship Award

Publications + National Presentations

1. Myers KM, Feltovich H, Mazza E, Vink J, Bajka M, Wapner RJ, Hall TJ, House M. The mechanical role of the cervix in pregnancy. J Biomech. 2015 Jun 25;48(9):1511-23. doi: 10.1016/j.jbiomech.2015.02.065. Epub 2015 Mar 11. PubMed PMID: 25841293; PubMed Central PMCID: PMC4459908.

2. Feltovich H, House M. Innovative methods of cervical assessment and potential for novel treatment. Clin Obstet Gynecol. 2014 Sep;57(3):531-6. doi: 10.1097/GRF.0000000000000049. Review. PubMed PMID: 25084285; PubMed Central PMCID: PMC4120240.

3. Critchfield AS, Mccabe R, Klebanov N, Richey L, Socrate S, Norwitz ER, Kaplan DL, House M. Biocompatibility of a sonicated silk gel for cervical injection during pregnancy: in vivo and in vitro study. Reprod Sci. 2014 Oct;21(10):1266-73. doi: 10.1177/1933719114522551. Epub 2014 Feb 11. PubMed PMID: 24520079.

4. House M, Tadesse-Telila S, Norwitz ER, Socrate S, Kaplan DL. Inhibitory effect of progesterone on cervical tissue formation in a three-dimensional culture system with human cervical fibroblasts. Biol Reprod. 2014 Jan 30;90(1):18. doi: 10.1095/biolreprod.113.112540. Print 2014 Jan. PubMed PMID: 24285720; PubMed Central PMCID: PMC4076401.

5. Critchfield AS, Yao G, Jaishankar A, Friedlander RS, Lieleg O, Doyle PS, McKinley G, House M, Ribbeck K. Cervical mucus properties stratify risk for preterm birth. PLoS One. 2013 Aug 1;8(8):e69528. doi: 10.1371/journal.pone.0069528. Print 2013. PubMed PMID: 23936335; PubMed Central PMCID: PMC3731331.

6. Heard AJ, Socrate S, Burke KA, Norwitz ER, Kaplan DL, House MD. Silk-based injectable biomaterial as an alternative to cervical cerclage: an in vitro study. Reprod Sci. 2013 Aug;20(8):929-36. doi: 10.1177/1933719112468952. Epub 2012 Dec 27. PubMed PMID: 23271162; PubMed Central PMCID: PMC3713644.

7. House M, McCabe R, Socrate S. Using imaging-based, three-dimensional models of the cervix and uterus for studies of cervical changes during pregnancy. Clin Anat. 2013 Jan;26(1):97-104. doi: 10.1002/ca.22183. Epub 2012 Nov 21. Review. PubMed PMID: 23168534.

8. House M, Daniel J, Elstad K, Socrate S, Kaplan DL. Oxygen tension and formation of cervical-like tissue in two-dimensional and three-dimensional culture. Tissue Eng Part A. 2012 Mar;18(5-6):499-507. doi: 10.1089/ten.TEA.2011.0309. Epub 2011 Nov 1. PubMed PMID: 21919792; PubMed Central PMCID: PMC3286821.

9. Myers KM, Socrate S, Paskaleva A, House M. A study of the anisotropy and tension/compression behavior of human cervical tissue. J Biomech Eng. 2010 Feb;132(2):021003. doi: 10.1115/1.3197847. PubMed PMID: 20370240.

10. House M, Sanchez CC, Rice WL, Socrate S, Kaplan DL. Cervical tissue engineering using silk scaffolds and human cervical cells. Tissue Eng Part A. 2010 Jun;16(6):2101-12. doi: 10.1089/ten.TEA.2009.0457. PubMed PMID: 20121593; PubMed Central PMCID: PMC2949265.

News, Media + Videos

Al Charest, MSc, PhD, a researcher at Tufts Medical Center.

Tufts MC announces inaugural INNOVATION Day: Innovating a path to market.

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Research Grants

NIH 1R01HD084695-01A1
“Mechanisms of Infection-Mediated Cervical Ripening.”
The goal of this project is to acquire a greater mechanistic understanding of biochemical pathways leading to cervical ripening, with a particular emphasis on infection-mediated cervical ripening.
Role: Co-Investigator

MIT: Burroughs Wellcome Fund
Sub Award #5710003419 2013-2017
Properties and Functions of Cervical Mucus Associated with Preterm Birth
The goal is to increase understanding of the basic biological mechanisms underlying parturition and spontaneous birth using multidisciplinary approaches.
Role: TMC Principal Investigator

NICHD Scholar of the RSDP
K12HD000849 2007-2013
Cervical Tissue Engineering for Studying Obstetrical Biomechanics.
The goal is to use a tissue engineering strategy to study mechanisms of cervical remodeling during pregnancy.
Role: Principal Investigator

Burroughs Wellcome Fund – Preterm Birth Initiative
Beyond Cervical Length: Development of a Patient-Specific Model of Cervical Mechanical Function during Pregnancy.
The goal of this study was to determine biomechanical function of the cervix during pregnancy by combining three-dimensional ultrasound with biomechanical models of cervical mechanics.
Role: Principal Investigator

Research Focus

Dr. House's research focus is on studying the role of the cervix in normal and high-risk pregnancy. Normal cervical function is critical for a healthy pregnancy but premature cervical shortening and dilation is associated with preterm birth, which affects 12% of pregnancies in the United States. Research activities include 1) design and evaluation of three-dimensional models of cervical tissue to study remodeling of the cervical extracellular matrix, 2) investigation of the cervical biomechanical function using mechanical modeling techniques, 3) study of the barrier properties of cervical mucus as it relates to protection against intrauterine infection and 4) development of novel therapies such as injectable biomaterials to augment cervical function during pregnancy. This research is valuable for understanding why the cervix stays closed in normal pregnancy but shortens and opens in preterm birth. Successful accomplishment of this research relies on a collaborative multidisciplinary research team involving investigators with expertise in mechanical engineering, biology and maternal fetal medicine.